Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T02551 Target Info
Target Name Dopamine D3 receptor (D3R)
Synonyms D(3) dopamine receptor
Target Type Successful Target
Gene Name DRD3
Biochemical Class GPCR rhodopsin
UniProt ID
DRD3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Eticlopride Ligand Info
Structure Description Structure of the human dopamine D3 receptor in complex with eticlopride PDB:3PBL
Method X-ray diffraction Resolution 2.89 Å Mutation Yes [1]
PDB Sequence
YALSYCALIL
41
AIVFGNGLVC
51
MAVLKERALQ
61
TTTNYLVVSL
71
AVADLLVATL
81

VMPWVVYLEV
91
TGGVWNFSRI
101
CCDVFVTLDV
111
MMCTASIWNL
121
CAISIDRYTA
131

VVMPVHYQHG
141
TGQSSCRRVA
151
LMITAVWVLA
161
FAVSCPLLFG
171
FNTTGDPTVC
181

SISNPDFVIY
191
SSVVSFYLPF
201
GVTVLVYARI
211
YVVLKQRRRK
221
NIFEMLRIDE
1011

GLRLKIYKDT
1021
EGYYTIGIGH
1031
LLTKSPSLNA
1041
AKSELDKAIG
1051
RNTNGVITKD
1061

EAEKLFNQDV
1071
DAAVRGILRN
1081
AKLKPVYDSL
1091
DAVRRAALIN
1101
MVFQMGETGV
1111

AGFTNSLRML
1121
QQKRWDEAAV
1131
NLAKSRWYNQ
1141
TPNRAKRVIT
1151
TFRTGTWDAY
1161

GVPLREKKAT
328
QMVAIVLGAF
338
IVCWLPFFLT
348
HVLNTHCQTC
358
HVSPELYSAT
368

TWLGYVNSAL
378
NPVIYTTFNI
388
EFRKAFLKIL
398
SC
Residue
Distance (Å)
VAL86
4.444
PHE106
3.635
VAL107
4.269
ASP110
2.702
VAL111
3.444
CYS114
3.583
THR115
4.791
ILE183
3.496
VAL189
3.756
SER192
3.330
Residue
Distance (Å)
SER193
3.947
SER196
4.601
TRP342
4.043
PHE345
3.189
PHE346
3.718
HIS349
3.091
VAL350
4.684
TYR365
3.978
THR369
3.581
TYR373
3.145
References  Top
REF 1 Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science. 2010 Nov 19;330(6007):1091-5.

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