Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13491 Target Info
Target Name Solute carrier family 29 member 1 (SLC29A1)
Synonyms SLC29A1; Nucleoside transporter, es-type; Nucleoside transporter 1; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; ENT1
Target Type Successful Target
Gene Name SLC29A1
UniProt ID
S29A1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Dilazep Ligand Info
Structure Description Human equilibrative nucleoside transporter-1, dilazep bound PDB:6OB7
Method X-ray diffraction Resolution 2.30 Å Mutation Yes [1]
PDB Sequence
PQDRYKAVWL
16
IFFMLGLGTL
26
LPWNFFMTAT
36
QYFTNRLDMS
46
QNNSLSAIFN
81

NVMTLCAMLP
91
LLLFTYLNSF
101
LHQRIPQSVR
111
ILGSLVAILL
121
VFLITAILVK
131

VQLDALPFFV
141
ITMIKIVLIN
151
SFGAILQGSL
161
FGLAGLFPAS
171
YTAAIMSGQG
181

LAGFFASVAM
191
ICAIASGSEL
201
SESAFGYFIT
211
ACAVIILTII
221
CYLGLPRLEF
231

YRYYQQLKLS
281
IKAILKKISV
291
LAFSVCFIFT
301
ITIGMFPAVT
311
VEVKSSIAGS
321

STWERYFIPV
331
SCFLTFNIFD
341
WLGRSLTAVF
351
MWPGKDSRWL
361
PSLVLARLVF
371

VPLLLLCNIK
381
PRRYLTVVFE
391
HDAWFIFFMA
401
AFAFSNGYLA
411
SLCMCFGPKK
421

VKPAEAETAG
431
AIMAFFLCLG
441
LALGAVFSFL
451
F
Residue
Distance (Å)
THR25
4.937
LEU26
2.522
TRP29
1.981
ASN30
2.970
MET33
2.217
THR34
2.008
THR36
2.603
ASN81
3.550
MET84
2.226
THR85
2.687
ALA88
3.530
MET89
2.611
LEU92
2.722
ASN151
3.044
GLY154
3.801
GLN158
2.299
PHE162
3.957
GLN180
3.519
ALA183
4.637
Residue
Distance (Å)
GLY184
2.313
ALA187
2.751
SER188
2.371
MET191
2.736
PHE300
2.517
ILE304
2.286
PHE307
2.828
PRO308
2.704
ALA309
4.616
PHE334
2.808
PHE337
4.358
ASN338
2.556
ARG345
2.800
ASN407
4.267
LEU438
2.224
CYS439
3.774
LEU442
2.387
ALA446
3.304
Ligand Name: S6-nitrobenzyl mercaptopurine riboside Ligand Info
Structure Description Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned PDB:6OB6
Method X-ray diffraction Resolution 2.90 Å Mutation Yes [1]
PDB Sequence
PQDRYKAVWL
16
IFFMLGLGTL
26
LPWNFFMTAT
36
QYFTNRLDMN
74
SLSAIFNNVM
84

TLCAMLPLLL
94
FTYLNSFLHQ
104
RIPQSVRILG
114
SLVAILLVFL
124
ITAILVKVQL
134

DALPFFVITM
144
IKIVLINSFG
154
AILQGSLFGL
164
AGLFPASYTA
174
AIMSGQGLAG
184

FFASVAMICA
194
IASGSELSES
204
AFGYFITACA
214
VIILTIICYL
224
GLPRLEFYRY
234

YQQSIKAILK
287
KISVLAFSVC
297
FIFTITIGMF
307
PAVTVEVKSS
317
RYFIPVSCFL
335

TFNIFDWLGR
345
SLTAVFMWPG
355
KDSRWLPSLV
365
LARLVFVPLL
375
LLCNIKPRRY
385

LTVVFEHDAW
395
FIFFMAAFAF
405
SNGYLASLCM
415
CFGPKKVKPA
425
EAETAGAIMA
435

FFLCLGLALG
445
AVFSF
Residue
Distance (Å)
GLY24
3.614
THR25
2.741
LEU26
2.072
PRO28
3.118
TRP29
2.324
ASN30
4.484
MET33
4.028
MET89
4.334
LEU92
2.372
LEU116
4.622
ILE119
2.406
PHE123
4.290
ILE150
2.548
ASN151
3.092
GLY154
2.564
ALA155
4.193
Residue
Distance (Å)
LEU157
2.327
GLN158
2.201
PHE162
4.482
GLN180
3.030
GLY181
4.825
PHE300
2.045
THR303
2.391
ILE304
2.431
PHE307
2.748
PHE337
1.962
ASP341
3.138
ARG345
2.518
ASN407
3.210
LEU438
3.126
CYS439
4.725
LEU442
3.192
References  Top
REF 1 Structures of human ENT1 in complex with adenosine reuptake inhibitors. Nat Struct Mol Biol. 2019 Jul;26(7):599-606.

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