Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13616 Target Info
Target Name Integrin-linked protein kinase 1 (ILK)
Synonyms P59ILK; Integrin-linked protein kinase; Integrin-linked kinase; ILK2; ILK1; ILK-2; ILK-1; Beta-integrin-linked kinase; 59 kDa serine/threonine-protein kinase; 59 kDa serine/threonine protein kinase
Target Type Patented-recorded Target
Gene Name ILK
Biochemical Class Kinase
UniProt ID
ILK_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Adenosine triphosphate Ligand Info
Structure Description Crystal structure of the ILK/alpha-parvin core complex (MnATP) PDB:3REP
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [1]
PDB Sequence
HSGIDFKQLN
194
FLTKLNENHS
204
GELWKGRWQG
214
NDIVVKVLKV
224
RDWSTRKSRD
234

FNEECPRLRI
244
FSHPNVLPVL
254
GACQSPPAPH
264
PTLITHWMPY
274
GSLYNVLHEG
284

TNFVVDQSQA
294
VKFALDMARG
304
MAFLHTLEPL
314
IPRHALNSRS
324
VMIDEDMTAR
334

ISMADVKFSF
344
QSPGRMYAPA
354
WVAPEALQKK
364
PEDTNRRSAD
374
MWSFAVLLWE
384

LVTREVPFAD
394
LSNMEIGMKV
404
ALEGLRPTIP
414
PGISPHVSKL
424
MKICMNEDPA
434

KRPKFDMIVP
444
ILEKMQDK
Residue
Distance (Å)
LEU199
4.554
ASN200
2.920
ASN202
2.985
HIS203
3.577
SER204
2.553
LEU207
2.993
VAL218
3.647
LYS220
2.683
LEU251
4.148
THR269
3.654
HIS270
2.894
Residue
Distance (Å)
TRP271
3.448
MET272
2.869
GLY275
4.046
SER276
4.471
ASN279
2.486
ARG323
3.614
MET326
3.637
ASP339
2.996
LYS341
3.040
GLN345
4.622
Click to View More Binding Site Information of This Target and Ligand Pair
References  Top
REF 1 Crystal structure of the ILK/alpha-parvin core complex (MnATP)

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