Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T19011 Target Info
Target Name M-phase inducer phosphatase 3 (MPIP3)
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Target Type Literature-reported Target
Gene Name CDC25C
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
MPIP3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: L-serine-O-phosphate Ligand Info
Structure Description The molecular tweezer CLR01 stabilizes a disordered protein-protein interface PDB:5M37
Method X-ray diffraction Resolution 2.35 Å Mutation No [1]
PDB Sequence
SRSGLYRSPM
217
PENLNRP
Residue
Distance (Å)
ARG213
3.027
SER214
2.799
PRO215
1.332
Residue
Distance (Å)
MET217
1.337
PRO218
3.334
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Ligand Name: [(1S,5R,9R,16S,20S,24R,28R,35S)-22-phosphonooxy-3-tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2,4(21),6(19),7,10,12,14,17,22,25(38),26,29,31,33,36-pentadecaenyl] dihydrogen phosphate Ligand Info
Structure Description The molecular tweezer CLR01 stabilizes a disordered protein-protein interface PDB:5M37
Method X-ray diffraction Resolution 2.35 Å Mutation No [1]
PDB Sequence
SRSGLYRSPM
217
PENLNRP
Residue
Distance (Å)
ARG208
2.698
SER209
3.690
Residue
Distance (Å)
GLY210
4.800
TYR212
3.567
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References  Top
REF 1 The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J Am Chem Soc. 2017 Nov 15;139(45):16256-16263.

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