Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T19784 Target Info
Target Name Somatotropin (GH1)
Synonyms Pituitary growth hormone; Growth hormone 1; Growth hormone; GH-N; GH
Target Type Clinical trial Target
Gene Name GH1
Biochemical Class Somatotropin/prolactin
UniProt ID
SOMA_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (2S)-6-acetamido-2-[[2-[2-[2-[[(4R)-4-carboxy-4-[[(4S)-4-carboxy-4-[[2-[2-[2-[4-[16-(2H-tetrazol-5-yl)hexadecanoylsulfamoyl]butanoylamino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]butanoyl]amino]ethoxy]ethoxy]acetyl]amino]hexanoic acid Ligand Info
Structure Description Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan PDB:6QIO
Method X-ray diffraction Resolution 1.95 Å Mutation Yes [1]
PDB Sequence
C
Residue
Distance (Å)
CYS101
1.800
Residue
Distance (Å)
References  Top
REF 1 Identification of Binding Sites on Human Serum Albumin for Somapacitan, a Long-Acting Growth Hormone Derivative. Biochemistry. 2020 Apr 14;59(14):1410-1419.

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