Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T24836 Target Info
Target Name Vitamin K-dependent protein C (PROC)
Synonyms Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; PROC; Blood coagulation factor XIV; Autoprothrombin IIA; Anticoagulant protein C; Activation peptide
Target Type Successful Target
Gene Name PROC
Biochemical Class Peptidase
UniProt ID
PROC_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Gamma-Carboxy-Glutamic Acid Ligand Info
Structure Description Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. PDB:1LQV
Method X-ray diffraction Resolution 1.60 Å Mutation Yes [1]
PDB Sequence
ANSFLLRHSS
12
LRCIICDFAK
28
IFQN
Residue
Distance (Å)
ALA1
2.720
ASN2
2.999
SER3
2.978
PHE4
3.112
LEU5
1.338
LEU8
1.348
ARG9
2.855
HIS10
4.861
SER11
3.259
SER12
2.813
LEU13
1.332
ARG15
1.329
Residue
Distance (Å)
CYS17
1.327
ILE18
1.347
ILE21
1.326
CYS22
3.188
ASP23
2.898
PHE24
1.330
ALA27
1.336
LYS28
1.338
ILE30
1.336
PHE31
3.593
GLN32
3.013
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Ligand Name: phosphatidylethanolamine Ligand Info
Structure Description Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. PDB:1LQV
Method X-ray diffraction Resolution 1.60 Å Mutation Yes [1]
PDB Sequence
ANSFLLRHSS
12
LRCIICDFAK
28
IFQN
Residue
Distance (Å)
PHE4
4.282
Residue
Distance (Å)
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References  Top
REF 1 The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem. 2002 Jul 12;277(28):24851-4.

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