Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28692 | Target Info | |||
| Target Name | Lipoprotein lipase (LPL) | ||||
| Synonyms | LIPD | ||||
| Target Type | Successful Target | ||||
| Gene Name | LPL | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 7-(3-cyano-4-hydroxyphenyl)-N-[2-(morpholin-4-yl)ethyl]dibenzo[b,f]oxepine-10-carboxamide | Ligand Info | |||||
| Structure Description | Compound 2 bound structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells | PDB:6OB0 | ||||
| Method | X-ray diffraction | Resolution | 2.81 Å | Mutation | Yes | [1] |
| PDB Sequence |
QRRDFIDIES
39 KFALRTPEDT49 AEDTCHLIPG59 VAESVATCHF69 NHSSKTFMVI79 HGWTVTGMYE 89 SWVPKLVAAL99 YKREPDSNVI109 VVDWLSRAQE119 HYPVSAGYTK129 LVGQDVARFI 139 NWMEEEFNYP149 LDNVHLLGYS159 LGAHAAGIAG169 SLTNKKVNRI179 TGLDPAGPNF 189 EYAEAPSRLS199 PDDADFVDVL209 HTFTRGSPGR219 SIGIQKPVGH229 VDIYPNGGTF 239 QPGCNIGEAI249 RVIAERGLGD259 VDQLVKCSHE269 RSIHLFIDSL279 LNEENPSKAY 289 RCSSKEAFEK299 GLCLSCRKNR309 CNNLGYEINK319 VRAKRSSKMY329 LKTRSQMPYK 339 VFHYQVKIHF349 SGTESETHTN359 QAFEISLYGT369 VAESENIPFT379 LPEVSTNKTY 389 SFLIYTEVDI399 GELLMLKLKW409 KSDSYFSWSD419 WWSSPGFAIQ429 KIRVKAGETQ 439 KKVIFCSREK449 VSHLQKGKAP459 AVFVKCHDKS469 LN
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of lipoprotein lipase in complex with GPIHBP1. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10360-10365. | ||||
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