Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T29678 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.2 (SCN2A) | ||||
| Synonyms | Voltage-gated sodium channelsubunit alpha Nav1.2; Sodium channel protein type II subunit alpha; Sodium channel protein brainII subunit alpha; SCN2A; HBSC II | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SCN2A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | Ligand Info | |||||
| Structure Description | Human Nav1.2-beta2-KIIIA ternary complex | PDB:6J8E | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
PIRKLAIKIL
126 VHSLFNMLIM136 CTILTNCVFM146 TMSNPPDWTK156 NVEYTFTGIY166 TFESLIKILA 176 RGFCLEDFTF186 LRDPWNWLDF196 TVITFAYVTE206 FVDLGNVSAL216 RTFRVLRALK 226 TISVIPGLKT236 IVGALIQSVK246 KLSDVMILTV256 FCLSVFALIG266 LQLFMGNLRN 276 KCLQWPPDFN315 WDEYIEDKSH325 FYFLEGQNDA335 LLCGNSSDAG345 QCPEGYICVK 355 AGRNPNYGYT365 SFDTFSWAFL375 SLFRLMTQDF385 WENLYQLTLR395 AAGKTYMIFF 405 VLVIFLGSFY415 LINLILAVVA425 MAYEEQNQAT435 LEEAEQDCCK743 PWLKVKHLVN 753 LVVMDPFVDL763 AITICIVLNT773 LFMAMEHYPM783 TEQFSSVLSV793 GNLVFTGIFT 803 AEMFLKIIAM813 DPYYYFQEGW823 NIFDGFIVSL833 SLMELGLANV843 EGLSVLRSFR 853 LLRVFKLAKS863 WPTLNMLIKI873 IGNSVGALGN883 LTLVLAIIVF893 IFAVVGMQLF 903 GKSYKECVCK913 ISNDCELPRW923 HMHDFFHSFL933 IVFRVLCGEW943 IETMWDCMEV 953 AGQTMCLTVF963 MMVMVIGNLV973 VLNLFLALLL983 SSFSGKLWWN1196 LRKTCYKIVE 1206 HNWFETFIVF1216 MILLSSGALA1226 FEDIYIEQRK1236 TIKTMLEYAD1246 KVFTYIFILE 1256 MLLKWVAYGF1266 QVYFTNAWCW1276 LDFLIVDVSL1286 VSLTANALGY1296 SELGAIKSLR 1306 TLRALRPLRA1316 LSRFEGMRVV1326 VNALLGAIPS1336 IMNVLLVCLI1346 FWLIFSIMGV 1356 NLFAGKFYHC1366 INYTTGEMFD1376 VSVVNNYSEC1386 KALIESNQTA1396 RWKNVKVNFD 1406 NVGLGYLSLL1416 QVATFKGWMD1426 IMYAAVDSRN1436 VELQPKYEDN1446 LYMYLYFVIF 1456 IIFGSFFTLN1466 LFIGVIIDNF1476 NQQKKKFGGQ1486 DIFMTEEQKK1496 YYNAMKKLGS 1506 KKPQKPIPRP1516 ANKFQGMVFD1526 FVTKQVFDIS1536 IMILICLNMV1546 TMMVETDDQS 1556 QEMTNILYWI1566 NLVFIVLFTG1576 ECVLKLISLR1586 YYYFTIGWNI1596 FDFVVVILSI 1606 VGMFLAELIE1616 KYFVSPTLFR1626 VIRLARIGRI1636 LRLIKGAKGI1646 RTLLFALMMS 1656 LPALFNIGLL1666 LFLVMFIYAI1676 FGMSNFAYVK1686 REVGIDDMFN1696 FETFGNSMIC 1706 LFQITTSAGW1716 DGLLAPILNS1726 GPPDCDPDKD1736 HPGSSVKGDC1746 GNPSVGIFFF 1756 VSYIIISFLV1766 VVNMYIAVIL1776 ENFSVATEE
|
|||||
|
|
LEU421
3.333
ALA425
3.644
GLU429
4.794
PHE978
3.661
LEU979
3.555
LEU982
3.619
LEU983
3.727
PHE986
4.075
LEU1465
4.174
ILE1469
4.059
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular basis for pore blockade of human Na(+) channel Na(v)1.2 by the u-conotoxin KIIIA. Science. 2019 Mar 22;363(6433):1309-1313. | ||||
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