Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34429 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | ||||
| Synonyms | Nicotinic acetylcholine receptor subunit alpha 7; Nicotinic acetylcholine receptor alpha7; CHRNA7; Alpha7 nicotinic receptor; Alpha7 nAChR; Alpha-7 nAChR; Alpha(7) nicotinic receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | CHRNA7 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: EVP-6124 | Ligand Info | |||||
| Structure Description | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | PDB:7EKP | ||||
| Method | Electron microscopy | Resolution | 2.85 Å | Mutation | No | [1] |
| PDB Sequence |
GEFQRKLYKE
32 LVKNYNPLER42 PVANDSQPLT52 VYFSLSLLQI62 MDVDEKNQVL72 TTNIWLQMSW 82 TDHYLQWNVS92 EYPGVKTVRF102 PDGQIWKPDI112 LLYNSADERF122 DATFHTNVLV 132 NSSGHCQYLP142 PGIFKSSCYI152 DVRWFPFDVQ162 HCKLKFGSWS172 YGGWSLDLQM 182 QEADISGYIP192 NGEWDLVGIP202 GKRSERFYEC212 CKEPYPDVTF222 TVTMRRRTLY 232 YGLNLLIPCV242 LISALALLVF252 LLPADSGEKI262 SLGITVLLSL272 TVFMLLVAEI 282 MPATSDSVPL292 IAQYFASTMI302 IVGLSVVVTV312 IVLQYHHHDP322 DGGKMPKWTR 332 VILLNWCAWF342 LRMKRDLAKI436 LEEVRYIANR446 FRCQDESEAV456 CSEWKFAACV 466 VDRLCLMAFS476 VFTIICTIGI486 LMSAPNFVEA496 VSKDFA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | PDB:7EKP | ||||
| Method | Electron microscopy | Resolution | 2.85 Å | Mutation | No | [1] |
| PDB Sequence |
GEFQRKLYKE
32 LVKNYNPLER42 PVANDSQPLT52 VYFSLSLLQI62 MDVDEKNQVL72 TTNIWLQMSW 82 TDHYLQWNVS92 EYPGVKTVRF102 PDGQIWKPDI112 LLYNSADERF122 DATFHTNVLV 132 NSSGHCQYLP142 PGIFKSSCYI152 DVRWFPFDVQ162 HCKLKFGSWS172 YGGWSLDLQM 182 QEADISGYIP192 NGEWDLVGIP202 GKRSERFYEC212 CKEPYPDVTF222 TVTMRRRTLY 232 YGLNLLIPCV242 LISALALLVF252 LLPADSGEKI262 SLGITVLLSL272 TVFMLLVAEI 282 MPATSDSVPL292 IAQYFASTMI302 IVGLSVVVTV312 IVLQYHHHDP322 DGGKMPKWTR 332 VILLNWCAWF342 LRMKRDLAKI436 LEEVRYIANR446 FRCQDESEAV456 CSEWKFAACV 466 VDRLCLMAFS476 VFTIICTIGI486 LMSAPNFVEA496 VSKDFA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: PNU-120596 | Ligand Info | |||||
| Structure Description | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | PDB:7EKT | ||||
| Method | Electron microscopy | Resolution | 3.02 Å | Mutation | No | [1] |
| PDB Sequence |
GEFQRKLYKE
32 LVKNYNPLER42 PVANDSQPLT52 VYFSLSLLQI62 MDVDEKNQVL72 TTNIWLQMSW 82 TDHYLQWNVS92 EYPGVKTVRF102 PDGQIWKPDI112 LLYNSADERF122 DATFHTNVLV 132 NSSGHCQYLP142 PGIFKSSCYI152 DVRWFPFDVQ162 HCKLKFGSWS172 YGGWSLDLQM 182 QEADISGYIP192 NGEWDLVGIP202 GKRSERFYEC212 CKEPYPDVTF222 TVTMRRRTLY 232 YGLNLLIPCV242 LISALALLVF252 LLPADSGEKI262 SLGITVLLSL272 TVFMLLVAEI 282 MPATSDSVPL292 IAQYFASTMI302 IVGLSVVVTV312 IVLQYHHHDP322 DGGKMPKWTR 332 VILLNWCAWF342 LRMKRDLAKI436 LEEVRYIANR446 FRCQDESEAV456 CSEWKFAACV 466 VDRLCLMAFS476 VFTIICTIGI486 LMSAPNFVEA496 VSKDFA
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .I34 or .I342 or .I343 or :3I34;style chemicals stick;color identity;select .A:235 or .A:236 or .A:240 or .A:244 or .A:274 or .A:275 or .A:278; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of human Alpha7 nicotinic acetylcholine receptor activation. Cell Res. 2021 Jun;31(6):713-716. | ||||
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