Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T35799 Target Info
Target Name DNA mismatch repair protein Mlh1 (MLH1)
Synonyms MutL protein homolog 1; COCA2
Target Type Literature-reported Target
Gene Name MLH1
UniProt ID
MLH1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Crystal Structure of human MLH1 PDB:4P7A
Method X-ray diffraction Resolution 2.30 Å Mutation No [1]
PDB Sequence
FVAGVIRRLD
12
ETVVNRIAAG
22
EVIQRPANAI
32
KEMIENCLDA
42
KSTSIQVIVK
52

EGGLKLIQIQ
62
DNGTGIRKED
72
LDIVCERFTT
82
SKLGFRGEAL
104
ASISHVAHVT
114

ITTKTADGKC
124
AYRASYSDGK
134
LKAPPKPCAG
144
NQGTQITVED
154
LFYNIATRRK
164

ALKNPSEEYG
174
KILEVVGRYS
184
VHNAGISFSV
194
KKQGETVADV
204
RTLPNASTVD
214

NIRSIFGNAV
224
SRELIEIGCE
234
DKTLAFKMNG
244
YISNANYSVK
254
KCIFLLFINH
264

RLVESTSLRK
274
AIETVYAAYL
284
PKNTHPFLYL
294
SLEISPESIL
323
ERVQQHIESK
333

LLG
Residue
Distance (Å)
MET35
4.881
ASN38
3.053
CYS39
3.991
ASP41
4.592
ALA42
3.347
ASP63
2.923
THR66
4.682
GLY67
3.576
ILE68
3.391
VAL76
3.237
THR81
3.605
THR82
2.536
Residue
Distance (Å)
SER83
2.584
LYS84
2.784
PHE99
4.820
ARG100
3.408
GLY101
2.901
GLU102
3.985
ALA103
3.413
LEU104
2.915
ALA105
4.437
THR148
3.614
ILE150
4.589
References  Top
REF 1 Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):981-5.

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