Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49080 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv3.1 (KCNC1) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv4; Voltage-gated potassium channel subunit Kv3.1; Potassium voltage-gated channel subfamily C member 1; NGK2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KCNC1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Colfosceril palmitate | Ligand Info | |||||
| Structure Description | Human voltage-gated potassium channel Kv3.1 (with Zn) | PDB:7PHI | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
SERIVINVGG
16 TRHQTHRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALDRRWQPR175 IWALFEDPYS185 SRYARYVAFA195 SLFFILVSIT205 TFCLETHERF 215 NPIVNKTYYR237 EAETEAFLTY247 IEGVCVVWFT257 FEFLMRVIFC267 PNKVEFIKNS 277 LNIIDFVAIL287 PFYLEVGLSK301 AAKDVLGFLR311 VVRFVRILRI321 FKLTRHFVGL 331 RVLGHTLRAS341 TNEFLLLIIF351 LALGVLIFAT361 MIYYAERIGA371 QPNDPSASEH 381 THFKNIPIGF391 WWAVVTMTTL401 GYGDMYPQTW411 SGMLVGALCA421 LAGVLTIAMP 431 VPVIVNNFGM441 YYSLAMAKQK451 LPKKKKKHIP461 RPP
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl)pyrrole-3-carboxamide | Ligand Info | |||||
| Structure Description | Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563) | PDB:7PQU | ||||
| Method | Electron microscopy | Resolution | 3.03 Å | Mutation | No | [2] |
| PDB Sequence |
SERIVINVGG
16 TRHQTYRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALYARYVAF194 ASLFFILVSI204 TTFCLETHER214 FNPETEAFLT246 YIEGVCVVWF 256 TFEFLMRVIF266 CPNKIIDFVA285 ILPFYLEVGL310 RVVRFVRILR320 IFKLTRHFVG 330 LRVLGHTLRA340 STNEFLLLII350 FLALGVLIFA360 TMIYYAERIG370 ASASEHTHFK 385 NIPIGFWWAV395 VTMTTLGYGD405 MYPQTWSGML415 VGALCALAGV425 LTIAMPVPVI 435 VNNFGMYYSL445 AMAKQKLP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nat Commun. 2022 Jul 15;13(1):4087. | ||||
| REF 2 | Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators. PNAS Nexus. 2022 Jun 16;1(3):pgac083. | ||||
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