Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T53904 Target Info
Target Name HIF-prolyl hydroxylase 1 (HPH-1)
Synonyms Prolyl hydroxylase domain-containing protein 1; PHD1; Hypoxia-inducible factor prolyl hydroxylase 1; HPH-3; HIF-PH1; HIF-PH; Estrogen-induced tag6; Estrogen-induced tag 6; Egl nine homolog 2; EIT6; EIT-6
Target Type Successful Target
Gene Name EGLN2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
EGLN2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Phd-1-IN-1 Ligand Info
Structure Description Structure of PHD1 in complex with 1,2,4-Triazolo-[1,5-a]pyridine PDB:5V1B
Method X-ray diffraction Resolution 2.49 Å Mutation No [1]
PDB Sequence
PSAPERLALD
180
YIVPCMRYYG
190
ICVVDSFLGA
200
ALGGRVLAEV
210
EALKRGGRLR
220

QLVSPRSIRG
237
DQIAWVEGHE
247
PGCRSIGALM
257
AHVDAVIRHC
267
AGRLGSYKIN
277

GRTKAMVACY
287
PGNGLGYVRH
297
VDNPHGDGRC
307
ITCIYYLNQN
317
WDVKVHGGLL
327

QIFPEGRPVV
337
ANIEPLFDRL
347
LIFWSDRRNP
357
HEVKPAYATR
367
YAITVWYFDA
377

DERARAKDKY
387
QLASGQKGVQ
397
VPVSQP
Residue
Distance (Å)
ASP238
4.568
TYR287
3.458
TYR294
3.611
HIS297
3.115
ASP299
4.168
ILE311
3.611
TYR313
3.404
ASN315
3.146
Residue
Distance (Å)
LEU327
4.124
PRO342
3.732
PHE350
4.852
HIS358
3.126
VAL360
3.657
ARG367
3.338
TYR368
3.919
ALA369
3.784
References  Top
REF 1 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672.

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