Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T54229 Target Info
Target Name Angiogenin (ANG)
Synonyms Ribonuclease 5; RNase 5; RNASE5
Target Type Literature-reported Target
Gene Name ANG
Biochemical Class Endoribonucleases
UniProt ID
ANGI_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Glutathione Ligand Info
Structure Description Human angiogenin PD/ALS variant R121C PDB:5M9V
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [1]
PDB Sequence
DNSRYTHFLT
11
QHYDAKPQGR
21
DDRYCESIMR
31
RRGLTSPCKD
41
INTFIHGNKR
51

SIKAICENKN
61
GNPHRENLRI
71
SKSSFQVTTC
81
KLHGGSPWPP
91
CQYRATAGFR
101

NVVVACENGL
111
PVHLDQSIFC
121
R
Residue
Distance (Å)
ASP41
4.857
ILE42
3.920
GLN117
3.874
Residue
Distance (Å)
SER118
4.514
CYS121
2.039
Ligand Name: Pyrophosphate 2- Ligand Info
Structure Description Binding of Phosphate and Pyrophosphate ions at the active site of human Angiogenin as revealed by X-ray Crystallography PDB:1H52
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [2]
PDB Sequence
DNSRYTHFLT
11
QHYDAKPQGR
21
DDRYCESIMR
31
RRGLTSPCKD
41
INTFIHGNKR
51

SIKAICENKN
61
GNPHRENLRI
71
SKSSFQVTTC
81
KLHGGSPWPP
91
CQYRATAGFR
101

NVVVACENGL
111
PVHLDQSIFR
121
RP
Residue
Distance (Å)
PHE9
4.808
GLN12
2.721
HIS13
3.022
LYS40
3.412
ASN43
4.582
Residue
Distance (Å)
VAL113
4.218
HIS114
2.720
LEU115
2.514
ASP116
4.567
GLN117
3.139
References  Top
REF 1 Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis. Sci Rep. 2017 Feb 8;7:41996.
REF 2 Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. Protein Sci. 2001 Aug;10(8):1669-76.

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