Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Target Poor or Non Binders
Target Regulators
Target Affiliated Biological Pathways
References
Drug Binding Sites of Target  Top
Ligand Name: Glutathione Ligand Info
Structure Description Human angiogenin PD/ALS variant R121C PDB:5M9V
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [3]
PDB Sequence
DNSRYTHFLT
11
QHYDAKPQGR
21
DDRYCESIMR
31
RRGLTSPCKD
41
INTFIHGNKR
51

SIKAICENKN
61
GNPHRENLRI
71
SKSSFQVTTC
81
KLHGGSPWPP
91
CQYRATAGFR
101

NVVVACENGL
111
PVHLDQSIFC
121
R
Residue
Distance (Å)
ASP41
4.857
ILE42
3.920
GLN117
3.874
Residue
Distance (Å)
SER118
4.514
CYS121
2.039
Ligand Name: Pyrophosphate 2- Ligand Info
Structure Description Binding of Phosphate and Pyrophosphate ions at the active site of human Angiogenin as revealed by X-ray Crystallography PDB:1H52
Method X-ray diffraction Resolution 2.00 Å Mutation Yes [4]
PDB Sequence
DNSRYTHFLT
11
QHYDAKPQGR
21
DDRYCESIMR
31
RRGLTSPCKD
41
INTFIHGNKR
51

SIKAICENKN
61
GNPHRENLRI
71
SKSSFQVTTC
81
KLHGGSPWPP
91
CQYRATAGFR
101

NVVVACENGL
111
PVHLDQSIFR
121
RP
Residue
Distance (Å)
PHE9
4.808
GLN12
2.721
HIS13
3.022
LYS40
3.412
ASN43
4.582
Residue
Distance (Å)
VAL113
4.218
HIS114
2.720
LEU115
2.514
ASP116
4.567
GLN117
3.139
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
Degree 1 Degree centrality 1.07E-04 Betweenness centrality 0.00E+00
Closeness centrality 1.43E-04 Radiality 5.80E-03 Clustering coefficient 0.00E+00
Neighborhood connectivity 2.00E+00 Topological coefficient 1.00E+00 Eccentricity 2
Download Click to Download the Full PPI Network of This Target

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