Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T54771 | Target Info | |||
| Target Name | Sodium/glucose cotransporter 1 (SGLT1) | ||||
| Synonyms | Solute carrier family 5 member 1; Na(+)/glucose cotransporter 1; NAGT; High affinity sodium-glucose cotransporter | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SLC5A1 | ||||
| Biochemical Class | Solute:sodium symporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: LX2761 | Ligand Info | |||||
| Structure Description | Structure of human SGLT1-MAP17 complex bound with LX2761 | PDB:7WMV | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
ETHELIRNAA
27 DISIIVIYFV37 VVMAVGLWAM47 FSTNRGTVGG57 FFLAGRSMVW67 WPIGASLFAS 77 NIGSGHFVGL87 AGTGAASGIA97 IGGFEWNALV107 LVVVLGWLFV117 PIYIKAGVVT 127 MPEYLRKRFG137 GQRIQVYLSL147 LSLLLYIFTK157 ISADIFSGAI167 FINLALGLNL 177 YLAIFLLLAI187 TALYTITGGL197 AAVIYTDTLQ207 TVIMLVGSLI217 LTGFAFHEVG 227 GYDAFMEKYM237 KAIPTIVSDG247 NTTFQEKCYT257 PRADSFHIFR267 DPLTGDLPWP 277 GFIFGMSILT287 LWYWCTDQVI297 VQRCLSAKNM307 SHVKGGCILC317 GYLKLMPMFI 327 MVMPGMISRI337 LYTEKIACVV347 PSECEKYCGT357 KVGCTNIAYP367 TLVVELMPNG 377 LRGLMLSVML387 ASLMSSLTSI397 FNSASTLFTM407 DIYAKVRKRA417 SEKELMIAGR 427 LFILVLIGIS437 IAWVPIVQSA447 QSGQLFDYIQ457 SITSYLGPPI467 AAVFLLAIFW 477 KRVNEPGAFW487 GLILGLLIGI497 SRMITEFAYG507 TGSCMEPSNC517 PTIICGVHYL 527 YFAIILFAIS537 FITIVVISLL547 TKPIPDVHLY557 RLCWSLRNSK567 EERIDLDATE 622 EEEKAMKMKM632 TDTSEKPLWR642 TVLNVNGIIL652 VTVAVFCHAY662 FA |
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ASN78
2.930
ILE79
4.988
GLY82
4.437
HIS83
2.607
GLY86
4.323
LEU87
3.163
THR90
3.489
ILE98
3.357
PHE101
3.336
GLU102
3.129
ALA105
3.282
ALA160
4.778
ASP273
3.994
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | CryoEM structure of SGLT1 at 3.4 A resolution | PDB:7SL8 | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [2] |
| PDB Sequence |
HELIRNAADI
29 SVIVIYFLLV39 MAVGLWSMFK49 RSMVWWPIGA72 SLFASNIGSG82 HFIGLAGTGA 92 ASGLAVGGFE102 WNALVLLLVL112 GWVFVPIYIK122 AGVVTMPEYL132 RKRFGGQRIQ 142 VYLSVLSLFL152 YIFTKISVDI162 FSGAIFINLA172 LGWNLYLSII182 LLLAITALYT 192 ITGGLAAVIY202 TDTLQTLIML212 IGALILMGFA222 FHEVGGYDAF232 MEKYMKAIPT 242 IVSDGNTTFQ252 EKCYTPRADS262 FHIFRDPLTG272 DLPWPGFIFG282 LTILALWYWC 292 TDQVIVQRCL302 AAKNMSHVKG312 GCILAGYLKL322 LPMFIMVMPG332 MISRILFPDK 342 VACVVPSECE352 KYCGTKVGCT362 NIAYPTLVVE372 LMPNGLRGLM382 LAVMLAALMS 392 SLTSIFNSAS402 TLFTMDIYAK412 VRKRASEKEL422 MIVGRLFVLF432 LVVVSIAWIP 442 IVQSAQSGQL452 FDYIQSVSSY462 LAPPVAAVFL472 LAIFWKRVNE482 QGAFWGLILG 492 LLLGLSRLIL502 EFAYGTGSCM512 EPSNCPTIIC522 GVHYLYFAII532 LFAISGIVTV 542 VVSLLTKPIP552 DVHLYRLCWS562 LRNSKEERIM630 KMTDTSEKPL640 WRTVLNINAI 650 LLLAVAIFCW660 GYFASNSLEV670 LF
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| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | CryoEM structure of SGLT1 at 3.15 Angstrom resolution | PDB:7SLA | ||||
| Method | Electron microscopy | Resolution | 3.15 Å | Mutation | No | [2] |
| PDB Sequence |
THELIRNAAD
28 ISVIVIYFLL38 VMAVGLWSMF48 KRSMVWWPIG71 ASLFASNIGS81 GHFIGLAGTG 91 AASGLAVGGF101 EWNALVLLLV111 LGWVFVPIYI121 KAGVVTMPEY131 LRKRFGGQRI 141 QVYLSVLSLF151 LYIFTKISVD161 IFSGAIFINL171 ALGWNLYLSI181 ILLLAITALY 191 TITGGLAAVI201 YTDTLQTLIM211 LIGALILMGF221 AFHEVGGYDA231 FMEKYMKAIP 241 TIVSDGNTTF251 QEKCYTPRAD261 SFHIFRDPLT271 GDLPWPGFIF281 GLTILALWYW 291 CTDQVIVQRC301 LAAKNMSHVK311 GGCILAGYLK321 LLPMFIMVMP331 GMISRILFPD 341 KVACVVPSEC351 EKYCGTKVGC361 TNIAYPTLVV371 ELMPNGLRGL381 MLAVMLAALM 391 SSLTSIFNSA401 STLFTMDIYA411 KVRKRASEKE421 LMIVGRLFVL431 FLVVVSIAWI 441 PIVQSAQSGQ451 LFDYIQSVSS461 YLAPPVAAVF471 LLAIFWKRVN481 EQGAFWGLIL 491 GLLLGLSRLI501 LEFAYGTGSC511 MEPSNCPTII521 CGVHYLYFAI531 ILFAISGIVT 541 VVVSLLTKPI551 PDVHLYRLCW561 SLRNSKEERI571 DLMKMTDTSE637 KPLWRTVLNI 647 NAILLLAVAI657 FCHAYFASNS667 LEVLF
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural mechanism of SGLT1 inhibitors. Nat Commun. 2022 Oct 28;13(1):6440. | ||||
| REF 2 | Structure and mechanism of the SGLT family of glucose transporters. Nature. 2022 Jan;601(7892):274-279. | ||||
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