Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T56051 Target Info
Target Name Ubiquitin thioesterase L1 (UCHL1)
Synonyms Ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxy-terminal hydrolase L1; UCH-L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
Target Type Preclinical Target
Gene Name UCHL1
Biochemical Class Peptidase
UniProt ID
UCHL1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Methyl 4-aminobutanoate Ligand Info
Structure Description Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester. PDB:3IFW
Method X-ray diffraction Resolution 2.40 Å Mutation Yes [1]
PDB Sequence
MQLKPMEINP
10
EMLNKVLYRL
20
GVAGQWRFVD
30
VLGLEEESLG
40
SVPAPACALL
50

LLFPLTAQHE
60
NFRKKQIEEL
70
KGQEVSPKVY
80
FMKQTIGNSC
90
GTIGLIHAVA
100

NNQDKLGFED
110
GSVLKQFLSE
120
TEKMSPEDRA
130
KCFEKNEAIQ
140
AAHDAVAQEG
150

QCRVDDKVNF
160
HFILFNNVDG
170
HLYELDGRMP
180
FPVNHGASSE
190
DTLLKDAAKV
200

CREFTEREQG
210
EVRFSAVALC
220
KAA
Residue
Distance (Å)
PRO5
4.571
MET6
4.879
LEU55
3.628
GLN84
2.906
ILE86
4.895
GLY87
4.111
ASN88
3.059
Residue
Distance (Å)
SER89
4.457
CYS90
1.803
ASN159
3.846
PHE160
3.255
HIS161
3.844
PHE162
4.523
ARG178
4.750
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide Ligand Info
Structure Description Structure of UCHL1 in complex with GK13S inhibitor PDB:7ZM0
Method X-ray diffraction Resolution 2.24 Å Mutation No [2]
PDB Sequence
PGSMQLKPME
7
INPEMLNKVL
17
SRLGVAGQWR
27
FVDVLGLEEE
37
SLGSVPAPAC
47

ALLLLFPLTA
57
QHENFRKKQI
67
EELKGQEVSP
77
KVYFMKQTIG
87
NSCGTIGLIH
97

AVANNQDKLG
107
FEDGSVLKQF
117
LSETEKMSPE
127
DRAKCFEKNE
137
AIQAAHDAVA
147

QEGQNFHFIL
164
FNNVDGHLYE
174
LDGRMPFPVN
184
HGASSEDTLL
194
KDAAKVCREF
204

TERERFSAVA
218
LCK
Residue
Distance (Å)
MET6
3.345
GLU7
3.495
ILE8
3.004
LEU52
3.642
GLN84
2.979
ILE86
4.997
GLY87
2.898
ASN88
4.116
Residue
Distance (Å)
SER89
4.301
CYS90
1.784
GLY91
4.520
ASN159
3.829
PHE160
3.361
HIS161
3.897
ARG213
3.875
References  Top
REF 1 Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9117-22.
REF 2 Structural basis for specific inhibition of the deubiquitinase UCHL1. Nat Commun. 2022 Oct 10;13(1):5950.

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