Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56923 | Target Info | |||
| Target Name | C-X-C chemokine receptor type 2 (CXCR2) | ||||
| Synonyms | Interleukin-8 receptor B; IL8RB; IL-8R B; IL-8 receptor type 2; High affinity interleukin-8 receptor B; GRO/MGSA receptor; CXCR-2; CXC-R2; CDw128b; CD182 | ||||
| Target Type | Successful Target | ||||
| Gene Name | CXCR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Cryo-EM structure of a class A GPCR monomer | PDB:6LFO | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
SSTLPPFLLD
35 AAPCEPESLE45 INKYFVVIIY55 ALVFLLSLLG65 NSLVMLVILY75 SRVGRSVTDV 85 YLLNLALADL95 LFALTLPIWA105 ASKVNGWIFG115 TFLCKVVSLL125 KEVNFYSGIL 135 LLACISVDRY145 LAIVHATRTL155 TQKRYLVKFI165 CLSIWGLSLL175 LALPVLLFRR 185 TVYSSNVSPA195 CYEDMGNNTA205 NWRMLLRILP215 QSFGFIVPLL225 IMLFCYGFTL 235 RTLFKAHMGQ245 KHRAMRVIFA255 VVLIFLLCWL265 PYNLVLLADT275 LMRTQVIQET 285 CERRNHIDRA295 LDATEILGIL305 HSCLNPLIYA315 FIGQKFRHGL325 LKILAIH |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of CXC chemokine receptor 2 activation and signalling. Nature. 2020 Sep;585(7823):135-140. | ||||
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