Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58992 | Target Info | |||
| Target Name | Opioid receptor delta (OPRD1) | ||||
| Synonyms | OPRD; Delta-type opioid receptor; Delta opioid receptor; DOR-1; D-OR-1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | OPRD1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Naltrindole | Ligand Info | |||||
| Structure Description | 1.8 A Structure of the human delta opioid 7TM receptor (PSI Community Target) | PDB:4N6H | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
DLEDNWETLN
1011 DNLKVIEKAD1021 NAAQVKDALT1031 KMRAAALDAQ1041 KATPPKLEDK1051 SPDSPEMKDF 1061 RHGFDILVGQ1071 IDDALKLANE1081 GKVKEAQAAA1091 EQLKTTRNAY1101 IQKYLGSPGA 40 RSASSLALAI50 AITALYSAVC60 AVGLLGNVLV70 MFGIVRYTKM80 KTATNIYIFN 90 LALADALATS100 TLPFQSAKYL110 METWPFGELL120 CKAVLSIDYY130 NMFTSIFTLT 140 MMSVDRYIAV150 CHPVKALDFR160 TPAKAKLINI170 CIWVLASGVG180 VPIMVMAVTR 190 PRDGAVVCML200 QFPSPSWYWD210 TVTKICVFLF220 AFVVPILIIT230 VCYGLMLLRL 240 RSVRLLSGSK250 EKDRSLRRIT260 RMVLVVVGAF270 VVCWAPIHIF280 VIVWTLVDID 290 RRDPLVVAAL300 HLCIALGYAN310 SSLNPVLYAF320 LDENFKRCFR330 QLCRKPCG |
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| Ligand Name: Oleic acid | Ligand Info | |||||
| Structure Description | 1.8 A Structure of the human delta opioid 7TM receptor (PSI Community Target) | PDB:4N6H | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
DLEDNWETLN
1011 DNLKVIEKAD1021 NAAQVKDALT1031 KMRAAALDAQ1041 KATPPKLEDK1051 SPDSPEMKDF 1061 RHGFDILVGQ1071 IDDALKLANE1081 GKVKEAQAAA1091 EQLKTTRNAY1101 IQKYLGSPGA 40 RSASSLALAI50 AITALYSAVC60 AVGLLGNVLV70 MFGIVRYTKM80 KTATNIYIFN 90 LALADALATS100 TLPFQSAKYL110 METWPFGELL120 CKAVLSIDYY130 NMFTSIFTLT 140 MMSVDRYIAV150 CHPVKALDFR160 TPAKAKLINI170 CIWVLASGVG180 VPIMVMAVTR 190 PRDGAVVCML200 QFPSPSWYWD210 TVTKICVFLF220 AFVVPILIIT230 VCYGLMLLRL 240 RSVRLLSGSK250 EKDRSLRRIT260 RMVLVVVGAF270 VVCWAPIHIF280 VIVWTLVDID 290 RRDPLVVAAL300 HLCIALGYAN310 SSLNPVLYAF320 LDENFKRCFR330 QLCRKPCG |
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ALA47
3.594
LEU48
3.835
ILE50
4.281
ALA51
3.883
ALA54
3.583
LEU55
3.528
ALA58
3.811
CYS60
4.375
LEU64
4.150
MET71
3.997
PHE72
3.842
VAL75
3.839
ALA83
4.516
TYR87
2.568
PHE89
4.231
LEU93
4.063
ALA96
3.956
LEU97
4.130
SER100
3.372
THR101
4.491
PRO103
3.757
PHE104
4.051
ALA107
4.212
PRO115
3.024
PHE116
3.347
GLY117
4.037
LEU120
4.504
VAL124
4.931
ILE127
4.078
MET141
3.957
VAL144
4.649
ASP145
2.709
ILE148
3.895
PHE159
3.301
ARG160
3.823
THR161
3.646
LYS164
3.891
ALA165
3.780
ILE168
3.717
TYR233
3.250
LEU237
3.726
ARG261
3.328
LEU264
4.076
VAL265
4.119
GLY268
3.886
ALA269
3.951
VAL271
4.172
VAL272
3.653
CYS273
4.017
ALA275
4.362
PRO276
3.737
ILE279
3.637
PHE280
3.952
VAL283
4.095
VAL287
3.710
ASP288
3.451
ILE289
3.612
ASP290
2.702
ASP293
3.174
LEU295
3.387
VAL296
3.543
ALA298
4.577
ALA299
4.120
LEU302
4.246
CYS303
4.234
LEU306
3.926
ALA309
4.042
LEU313
3.725
VAL316
3.694
LEU317
4.280
PHE320
3.506
LEU321
3.874
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | PDB:6PT2 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CLR or .CLR2 or .CLR3 or :3CLR;style chemicals stick;color identity;select .A:271 or .A:272 or .A:275 or .A:276 or .A:279 or .A:280 or .A:283 or .A:289 or .A:290 or .A:296 or .A:299 or .A:303; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: D-arginine | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | PDB:6PT2 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DAR or .DAR2 or .DAR3 or :3DAR;style chemicals stick;color identity;select .A:128 or .A:129 or .A:210 or .A:214 or .A:277 or .A:281 or .A:284 or .A:304; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Sarcosine | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | PDB:6PT2 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SAR or .SAR2 or .SAR3 or :3SAR;style chemicals stick;color identity;select .A:125 or .A:198 or .A:199 or .A:284; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-Dimethyl-L-tyrosine | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | PDB:6PT2 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DI7 or .DI72 or .DI73 or :3DI7;style chemicals stick;color identity;select .A:128 or .A:129 or .A:132 or .A:213 or .A:214 or .A:217 or .A:274 or .A:277 or .A:278 or .A:281 or .A:304 or .A:308; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: {[3,5-Bis(trifluoromethyl)phenyl]methyl}(methyl)amine | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the peptide agonist KGCHM07 | PDB:6PT2 | ||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OXJ or .OXJ2 or .OXJ3 or :3OXJ;style chemicals stick;color identity;select .A:277 or .A:280 or .A:281 or .A:284 or .A:289 or .A:291 or .A:296 or .A:300 or .A:304; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide | Ligand Info | |||||
| Structure Description | Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287 | PDB:6PT3 | ||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | No | [2] |
| PDB Sequence |
TMADLEDNWE
1008 TLNDNLKVIE1018 KADNAAQVKD1028 ALTKMRAAAL1038 DAQKATPPKL1048 EDKSPDSPEM 1058 KDFRHGFDIL1068 VGQIDDALKL1078 ANEGKVKEAQ1088 AAAEQLKTTR1098 NAYIQKYLRS 42 ASSLALAIAI52 TALYSAVCAV62 GLLGNVLVMF72 VIVRYTKMKT82 ATNIYIFSLA 92 LAGALATSTL102 PFQSADYLME112 TWPFGELLCK122 AVLSIDYYSM132 FTSIFTLTMM 142 CVDRYIAVCH152 PVKALDFRTP162 AKAKLINICI172 WVLASGVGVP182 IMVMAVTRPR 192 DGAVVCMLQF202 PSPSWYWDTV212 TKICVFLFAF222 VVPILIITVC232 YGLMLLRLRS 242 VRLLSGSKEK252 DRSLRRITRM262 VLVVVVAFVV272 CWAPIHIFVI282 VWTLVDIDRR 292 DPLVVAALHL302 CIALGYINSS312 LNPVLYAFLD322 KNFKRCF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OWY or .OWY2 or .OWY3 or :3OWY;style chemicals stick;color identity;select .A:98 or .A:128 or .A:129 or .A:131 or .A:132 or .A:135 or .A:214 or .A:217 or .A:274 or .A:277 or .A:278 or .A:280 or .A:281 or .A:284 or .A:300 or .A:304 or .A:307 or .A:308 or .A:311; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular control of Delta-opioid receptor signalling. Nature. 2014 Feb 13;506(7487):191-6. | ||||
| REF 2 | Elucidating the active Delta-opioid receptor crystal structure with peptide and small-molecule agonists. Sci Adv. 2019 Nov 27;5(11):eaax9115. | ||||
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