Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T59577 | Target Info | |||
Target Name | EBV-induced G-protein coupled receptor 2 (GPR183) | ||||
Synonyms | hEBI2; G-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2; EBI2 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | GPR183 | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 7alpha,25-dihydroxycholesterol | Ligand Info | |||||
Structure Description | Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein | PDB:7TUZ | ||||
Method | Electron microscopy | Resolution | 3.12 Å | Mutation | No | [1] |
PDB Sequence |
DLYAHHSTAR
31 IVMPLHYSLV41 FIIGLVGNLL51 ALVVIVQNRK61 KINSTTLYST71 NLVISDILFT 81 TALPTRIAYY91 AMGDALCRIT107 ALVFYINTYA117 GVNFMTCLSI127 DRFIAVVHPL 137 RYNKIKRIEH147 AKGVCIFVWI157 LVFAQTLPLL167 INPMSKITCM182 EYPNFEETKS 192 LPWILLGACF202 IGYVLPLIII212 LICYSQICCK222 LFRTAKQNPL232 TEKSGVNKKA 242 LNTIILIIVV252 FVLCFTPYHV262 AIIQHMIKKL272 RFSNFLECSQ282 RHSFQISLHF 292 TVCLMNFNCC302 MDPFIYFFAC312 KGYK
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Ligand Name: 8-[(E)-3-(4-Chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | Ligand Info | |||||
Structure Description | Cryo-EM structure of GSK682753A-bound EBI2/GPR183 | PDB:7TUY | ||||
Method | Electron microscopy | Resolution | 2.98 Å | Mutation | No | [1] |
PDB Sequence |
YAHHSTARIV
33 MPLHYSLVFI43 IGLVGNLLAL53 VVIVQNRKKI63 NSTTLYSTNL73 VISDILFTTA 83 LPTRIAYYAM93 GDALCRITAL109 VFYINTYAGV119 NFMTCLSIDR129 FIAVVHPLRY 139 NKIKRIEHAK149 GVCIFVWILV159 FAQTLPLLIN169 PMSKQTCMEY184 PNLPWILLGA 200 CFIGYVLPLI210 IILICYSQIC220 CKLFRARRQL1005 ADLEDNWETL1015 NDNLKVIEKA 1025 DNAAQVKDAL1035 TKMRAAALDA1045 QKASPEMKDF1066 RHGFDILVGQ1076 IDDALKLANE 1086 GKVKEAQAAA1096 EQLKTTRNAY1106 IQKYLERARS1116 TLSGVNKKAL233 NTIILIIVVF 243 VLCFTPYHVA253 IIQHMIKKLR263 FSQRHSFQIS279 LHFTVCLMNF289 NCCMDPFIYF 299 FACKGYKRKV309 M
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References | Top | ||||
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REF 1 | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure. 2022 Jul 7;30(7):1016-1024.e5. |
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