Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T84117 Target Info
Target Name 5-HT 1E receptor (HTR1E)
Synonyms Serotonin receptor 1E; S31; 5-hydroxytryptamine receptor 1E; 5-HT1E; 5-HT-1E; 5-HT 1E
Target Type Successful Target
Gene Name HTR1E
Biochemical Class GPCR rhodopsin
UniProt ID
5HT1E_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: BRL54443 Ligand Info
Structure Description Serotonin 1E (5-HT1E) receptor-Gi protein complex PDB:7E33
Method Electron microscopy Resolution 2.90 Å Mutation Yes [1]
PDB Sequence
TEKMLICMTL
29
VVITTLTTLL
39
NLAVIMAIGT
49
TKKLHQPANY
59
LICSLAVTDL
69

LVAVLVMPLS
79
IIYIVMDRWK
89
LGYFLCEVWL
99
SVDMTCCTCS
109
IWHLCVIALD
119

RYWAITNAIE
129
YARKRTAKRA
139
ALMILTVWTI
149
SIFISMPPLQ
172
CTIQHDHVIY
182

TIYSTLGAFY
192
IPLTLILILY
202
YRIYHAAKSL
212
SSTRERKAAR
291
ILGLILGAFI
301

LSWLPFFIKE
311
LIVGLSIYTV
321
SSEVADFLTW
331
LGYVNSLINP
341
LLYTSFNEDF
351

KLAFKKL
Residue
Distance (Å)
ASP102
3.061
MET103
3.718
CYS106
3.213
THR107
3.807
ILE153
4.867
HIS177
4.370
THR183
4.065
SER186
3.305
Residue
Distance (Å)
THR187
4.205
ALA190
4.067
TRP304
3.752
PHE307
3.494
PHE308
4.111
GLU311
2.388
THR330
3.495
TYR334
2.783
References  Top
REF 1 Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. 2021 Apr;592(7854):469-473.

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