Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86161 | Target Info | |||
| Target Name | Prolyl endopeptidase (PREP) | ||||
| Synonyms | Post-proline cleaving enzyme; PREP; PE | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PREP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (6s)-1-Chloro-3-[(4-Fluorobenzyl)oxy]-6-(Pyrrolidin-1-Ylcarbonyl)pyrrolo[1,2-A]pyrazin-4(6h)-One | Ligand Info | |||||
| Structure Description | Prolyl Oligopeptidase with GSK552 | PDB:3DDU | ||||
| Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | Yes | [1] |
| PDB Sequence |
LSFQYPDVYR
11 DETAVQDYHG21 HKICDPYAWL31 EDPDSEQTKA41 FVEAQNKITV51 PFLEQCPIRG 61 LYKERMTELY71 DYPKYSCHFK81 KGKRYFYFYN91 TGLQNQRVLY101 VQDSLEGEAR 111 VFLDPNILSD121 DGTVALRGYA131 FSEDGEYFAY141 GLSASGSDWV151 TIKFMKVDGA 161 KELPDVLERV171 KFSCMAWTHD181 GKGMFYNSYP191 QQDGKSDGTE201 TSTNLHQKLY 211 YHVLGTDQSE221 DILCAEFPDE231 PKWMGGAELS241 DDGRYVLLSI251 REGCDPVNRL 261 WYCDLQQESS271 GIAGILKWVK281 LIDNFEGEYD291 YVTNEGTVFT301 FKTNRHSPNY 311 RVINIDFTDP321 EESKWKVLVP331 EHEKDVLEWI341 ACVRSNFLVL351 CYLHDVKNTL 361 QLHDLTTGAL371 LKIFPLDVGS381 IVGYSGQKKD391 TEIFYQFTSF401 LSPGIIYHCD 411 LTKEELEPRV421 FREVVKIDAS433 DYQTVQIFYP443 SKDGTKIPMF453 IVHKKGIKLD 463 GSHPAFLYGY473 GGFNISITPN483 YSVSRLIFVR493 HMGGILAVAN503 IRGGGEYGET 513 WHKGGILANK523 QNCFDDFQCA533 AEYLIKEGYT543 SPKRLTINGG553 SNGGLLVAAC 563 ANQRPDLFGC573 VIAQVGVMDM583 LKFHKYTIGH593 AWTTDYGCSD603 SKQHFEWLVK 613 YSPLHNVKLP623 EADDIQYPSM633 LLLTADHDDR643 VVPLHSLKFI653 ATLQYIVGRS 663 RKQNNPLLIH673 VDTKAGHGAG683 KPTAKVIEEV693 SDMFAFIARC703 LNVDWIP |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP). Bioorg Med Chem Lett. 2008 Aug 1;18(15):4360-3. | ||||
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