Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88452 | Target Info | |||
| Target Name | Corticosteroid-binding globulin (SERPINA6) | ||||
| Synonyms | Transcortin; SERPINA6; CBG | ||||
| Target Type | Successful Target | ||||
| Gene Name | SERPINA6 | ||||
| Biochemical Class | Serpin protein | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Hydrocortisone | Ligand Info | |||||
| Structure Description | Crystal structure of the reactive loop cleaved Corticosteroid Binding Globulin complexed with Cortisol | PDB:2VDY | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
GLASANVDFA
25 FSLYKHLVAL35 SPKKNIFISP45 VSISMALAML55 SLGTCGHTRA65 QLLQGLGFNL 75 SETEIHQGFQ88 HLHQLFAKSD98 TSLEMTMGNA108 LFLDGSLELL118 ESFSADIKHY 128 YESEVLAMNF138 QDWATASRQI148 NSYVKNKTQG158 KIVDLFDSPA171 ILVLVNYIFF 181 KGTWTQPFDL191 ASTREENFYV201 DETTVVKVPM211 MLQSSTISYL221 HDSELPCQLV 231 QMNYVGNGTV241 FFILPDKGKM251 NTVIAALSRD261 TINRWSAGLT271 SSQVDLYIPK 281 VTISGVYDLG291 DVLEEMGIAD301 LFTTQANFSR311 ITQDAQLKSS321 KVVHKAVLQL 331 NEEGTEAAGA341 MFLEAIPRKP352 IILRFNQPFI362 IMIFDHFTWS372 SLFLARVMNP 382 V
|
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Progesterone | Ligand Info | |||||
| Structure Description | Crystal structure of cleaved corticosteroid-binding globulin in complex with progesterone | PDB:4BB2 | ||||
| Method | X-ray diffraction | Resolution | 2.48 Å | Mutation | Yes | [2] |
| PDB Sequence |
> Chain A
HHRGLASANV 22 DFAFSLYKHL32 VALSPKKNIF42 ISPVSISMAL52 AMLSLGTCGH62 TRAQLLQGLG 72 FNLTERSETE82 IHQGFQHLHQ92 LFALEMTMGN107 ALFLDGSLEL117 LESFSADIAH 127 YYESEVLAMN137 FQDWATASRQ147 INSYVKNKTQ157 GKIVDLFSGL167 DSPAILVLVN 177 YIFFKGTWTQ187 PFDLASTREE197 NFYVDETTVV207 KVPMMLQSST217 ISYLHDSELP 227 CQLVQMNYVG237 NGTVFFILPD247 KGKMNTVIAA257 LSRDTINRWS267 AGLTSSQVDL 277 YIPKVTISGV287 YDLGDVLEEM297 GIADLFTNQA307 NFSRITQDAQ317 LKSSKVVHKA 327 VLQLNEEGVD337 TAGSTGVTLN347 LT> Chain B KPIILRFNQP 360 FIIMIFDHFT370 WSSLFLARVM380 NPV
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release. J Mol Biol. 2008 Jun 27;380(1):244-51. | ||||
| REF 2 | Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.