Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88947 | Target Info | |||
| Target Name | Gap junction beta-2 protein (Cx26) | ||||
| Synonyms | Connexin-26 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GJB2 | ||||
| Biochemical Class | Gap junction-forming connexin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: phosphatidylethanolamine | Ligand Info | |||||
| Structure Description | human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4 | PDB:7QEQ | ||||
| Method | Electron microscopy | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
GTLQTILGGV
13 NKHSTSIGKI23 WLTVLFIFRI33 MILVVAAKEV43 WGDEQADFVC53 NTLQPGCKNV 63 CYDHYFPISH73 IRLWALQLIF83 VSTPALLVAM93 HVAYRRHEKK103 EGSLWWTYTS 138 SIFFRVIFEA148 AFMYVFYVMY158 DGFSMQRLVK168 CNAWPCPNTV178 DCFVSRPTEK 188 TVFTVFMIAV198 SGICILLNVT208 ELCYLLIRY
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Conformational changes and CO(2)-induced channel gating in connexin26. Structure. 2022 May 5;30(5):697-706.e4. | ||||
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