Target Information
| Target General Information | Top | |||||
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| Target ID |
T88947
(Former ID: TTDI03128)
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| Target Name |
Gap junction beta-2 protein (Cx26)
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| Synonyms |
Connexin-26
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| Gene Name |
GJB2
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. Structural component of gap junctions.
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| BioChemical Class |
Gap junction-forming connexin
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| UniProt ID | ||||||
| Sequence |
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC
KNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEE IKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDC FVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: phosphatidylethanolamine | Ligand Info | |||||
| Structure Description | human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4 | PDB:7QEQ | ||||
| Method | Electron microscopy | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
GTLQTILGGV
13 NKHSTSIGKI23 WLTVLFIFRI33 MILVVAAKEV43 WGDEQADFVC53 NTLQPGCKNV 63 CYDHYFPISH73 IRLWALQLIF83 VSTPALLVAM93 HVAYRRHEKK103 EGSLWWTYTS 138 SIFFRVIFEA148 AFMYVFYVMY158 DGFSMQRLVK168 CNAWPCPNTV178 DCFVSRPTEK 188 TVFTVFMIAV198 SGICILLNVT208 ELCYLLIRY
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Chemical Structure based Activity Landscape of Target | Top |
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| References | Top | |||||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 716). | |||||
| REF 2 | Conformational changes and CO(2)-induced channel gating in connexin26. Structure. 2022 May 5;30(5):697-706.e4. | |||||
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