Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94692 | Target Info | |||
| Target Name | Low-density lipoprotein receptor (LDL-R) | ||||
| Synonyms | LDL receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | LDLR | ||||
| Biochemical Class | Low density lipoprotein receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 12-TUNGSTOPHOSPHATE | Ligand Info | |||||
| Structure Description | Extracellular domain of the LDL receptor | PDB:1N7D | ||||
| Method | X-ray diffraction | Resolution | 3.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
SVTCKSGDFS
53 CGGNRCIPQF65 WRCDGQVDCN76 GSDEQGCPPK86 TCSQDEFRCH96 DGRQFVCDSD 110 RDCLDGSDEA120 SCPVLTCGPA130 SFQCNSSTCI140 PQLWACDNDP150 DCEDGSDEWP 160 QRCRGLYVFQ170 GDSSPCSAFE180 FHCLSGECIH190 SSWRCDGGPD200 CKDKSDEENC 210 AVATCRPDEF220 QCSDGNCIHG230 SRQCDREYDC240 KDMSDEVGCV250 NVTLCEGPNK 260 FKCHSGECIT270 LDKVCNMARD280 CRDWSDEPIK290 ECGTNECLDN300 NGGCSHVCND 310 LKIGYECLCP320 DGFQLVAQRR330 CEDIDECQDP340 DTCSQLCVNL350 EGGYKCQCEE 360 GFQLDPHTKA370 CKAVGSIAYL380 FFTNRHERKM391 TLDRSEYTSL401 IPNLRNVVAL 411 DTEVASNRIY421 WSDLSQRMIC431 STQLDRAHGS442 SYDTVISRDI452 PDGLAVDWIH 464 SNIYWTDSVL474 GTVSVADTKG484 VKRKTLFREQ494 GSKPRAIVVD504 PVHGFMYWTD 514 WGTPAKIKKG524 GLNGVDIYSL534 VTENIQWPNG544 ITLDLLSGRL554 YWVDSKLHSI 564 SSIDVNGGNR574 KTILEDEKRL584 AHPFSLAVFE594 DKVFWTDIIN604 EAIFSANRLT 614 GSDVNLLAEN624 LLSPEDMVLF634 HQLTQPRGVN644 WCERTTLSNG654 GCQYLCLPAP 664 QINPHSPKFT674 CACPDGMLLA684 RDMRSCLTE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the LDL receptor extracellular domain at endosomal pH. Science. 2002 Dec 20;298(5602):2353-8. | ||||
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