Target Information
Target General Information | Top | |||||
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Target ID |
T94692
(Former ID: TTDR00225)
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Target Name |
Low-density lipoprotein receptor (LDL-R)
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Synonyms |
LDL receptor
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Gene Name |
LDLR
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Lung cancer [ICD-11: 2C25] | |||||
Function |
In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis.
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BioChemical Class |
Low density lipoprotein receptor
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UniProt ID | ||||||
Sequence |
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVA Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
HIT2.0 ID | T49PL1 |
Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
1 | Porfimer Sodium | Drug Info | Approved | Non-small-cell lung cancer | [2] | |
Mode of Action | [+] 2 Modes of Action | + | ||||
Modulator | [+] 1 Modulator drugs | + | ||||
1 | Porfimer Sodium | Drug Info | [1] | |||
Inhibitor | [+] 1 Inhibitor drugs | + | ||||
1 | Alpha-D-Mannose | Drug Info | [3] |
Chemical Structure based Activity Landscape of Target | Top |
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Target Regulators | Top | |||||
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Target-regulating microRNAs | ||||||
Target-regulating Transcription Factors |
Target Profiles in Patients | Top | |||||
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Target Expression Profile (TEP) |
Target Affiliated Biological Pathways | Top | |||||
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KEGG Pathway | [+] 5 KEGG Pathways | + | ||||
1 | Endocytosis | |||||
2 | Ovarian steroidogenesis | |||||
3 | Bile secretion | |||||
4 | Toxoplasmosis | |||||
5 | Hepatitis C | |||||
NetPath Pathway | [+] 2 NetPath Pathways | + | ||||
1 | FSH Signaling Pathway | |||||
2 | IL2 Signaling Pathway | |||||
Reactome | [+] 3 Reactome Pathways | + | ||||
1 | LDL-mediated lipid transport | |||||
2 | Chylomicron-mediated lipid transport | |||||
3 | Retinoid metabolism and transport | |||||
WikiPathways | [+] 12 WikiPathways | + | ||||
1 | DNA Damage Response (only ATM dependent) | |||||
2 | Statin Pathway | |||||
3 | Wnt Signaling Pathway | |||||
4 | Wnt Signaling Pathway and Pluripotency | |||||
5 | Visual phototransduction | |||||
6 | Lipid digestion, mobilization, and transport | |||||
7 | Oncostatin M Signaling Pathway | |||||
8 | SREBF and miR33 in cholesterol and lipid homeostasis | |||||
9 | SREBP signalling | |||||
10 | Folate Metabolism | |||||
11 | Vitamin B12 Metabolism | |||||
12 | Selenium Micronutrient Network |
References | Top | |||||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
REF 3 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
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