Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95385 | Target Info | |||
| Target Name | Interleukin-12 beta (IL12B) | ||||
| Synonyms | NKSF2; NK cell stimulatory factor chain 2; Interleukin12 subunit beta; Interleukin-12 subunit beta; IL12 subunit p40; IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40 | ||||
| Target Type | Successful Target | ||||
| Gene Name | IL12B | ||||
| Biochemical Class | Cytokine: interleukin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-Mercapto-2-nitro-benzoic acid | Ligand Info | |||||
| Structure Description | THE P40 DOMAIN OF HUMAN INTERLEUKIN-12 | PDB:1F42 | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
IWELKKDVYV
10 VELDWYPDAP20 GEMVVLTCDT30 PEEDGITWTL40 DQSSEVLGSG50 KTLTIQVKEF 60 GDAGQYTCHK70 GGEVLSHSLL80 LLHKKEDGIW90 STDILKDQKE100 PKNKTFLRCE 110 AKNYSGRFTC120 WWLTTISTDL130 TFSVKSSRGG145 VTCGAATLSA155 ERVRGDNKEY 165 EYSVECQEDS175 ACPAAEESLP185 IEVMVDAVHK195 LKYENYTSSF205 FIRDIIKPDP 215 PKNLQLKPLK225 NSRQVEVSWE235 YPDTWSTPHS245 YFSLTFCVQV255 QGKSKRRVFT 269 DKTSATVICR279 KNASISVRAQ289 DRYYSSSWSE299 WASVPCS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. EMBO J. 2000 Jul 17;19(14):3530-41. | ||||
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