Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T97765 Target Info
Target Name Macrophage inflammatory protein 1-alpha (CCL3)
Synonyms Tonsillar lymphocyte LD78 alpha protein; Small-inducible cytokine A3; SIS-beta; SCYA3; PAT 464.1; Macrophage Inflammatory Protein-1alpha Nuclear Protein; MNP; MIP1A; MIP-1-alpha; G0S19-1 protein; G0S19-1; G0/G1 switch regulatory protein 19-1; C-C motif chemokine 3
Target Type Clinical trial Target
Gene Name CCL3
Biochemical Class Cytokine: CC chemokine
UniProt ID
CCL3_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Beta-D-Glucose Ligand Info
Structure Description X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX PDB:5D65
Method X-ray diffraction Resolution 3.10 Å Mutation No [1]
PDB Sequence
SLAADTPTAC
11
CFSYTSRQIP
21
QNFIADYFET
31
SSQCSKPGVI
41
FLTKRSRQVC
51

ADPSEEWVQK
61
YVSDLELS
Residue
Distance (Å)
TYR15
4.226
GLN19
2.743
GLN22
4.321
ILE25
3.648
ALA26
3.457
SER36
3.954
LYS37
4.106
PRO38
3.650
LYS45
4.248
Residue
Distance (Å)
ASP53
3.225
SER55
3.161
GLU56
3.756
GLU57
4.042
TRP58
3.984
LYS61
3.598
ASP65
3.945
LEU66
3.995
SER69
3.398
References  Top
REF 1 Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5000-5.

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