Content Navigation
( All
None )
Target General Information |
Top |
Target ID |
T59328 |
Target Info
|
Target Name |
Epidermal growth factor receptor (EGFR) |
Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB |
Target Type |
Successful Target |
Gene Name |
EGFR |
Biochemical Class |
Kinase |
UniProt ID |
|
Targeted Antigens of CAR-T Cell Therapy |
Top |
CAR T-Cell Therapy Drug(s) |
CART-EGFR |
Drug Info
|
Phase 1/2 |
Solid tumour/cancer |
[1] |
EGFR CART |
Drug Info
|
Phase 1/2 |
Colorectal cancer |
[2] |
Anti-EGFR CAR T |
Drug Info
|
Phase 1 |
Glioma |
[3] |
EGFR806-specific CAR T cell |
Drug Info
|
Phase 1 |
Pineoblastoma |
[4] |
References |
Top |
REF 1 |
ClinicalTrials.gov (NCT01869166) Treatment of Chemotherapy Refractory EGFR(Epidermal Growth Factor Receptor) Positive Advanced Solid Tumors (CART-EGFR)
|
REF 2 |
ClinicalTrials.gov (NCT03152435) EGFR CART Cells for Patients With Metastatic Colorectal Cancer
|
REF 3 |
ClinicalTrials.gov (NCT02331693) CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR
|
REF 4 |
ClinicalTrials.gov (NCT03638167) EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors
|
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.