Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02617 | Target Info | |||
| Target Name | Transferrin (TF) | ||||
| Synonyms | Siderophilin; Serotransferrin; PRO1400; Beta-1 metal-binding globulin | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TF | ||||
| Biochemical Class | Transferrin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Nitrilotriacetic acid | Ligand Info | |||
| Canonical SMILES | C(C(=O)O)N(CC(=O)O)CC(=O)O | ||||
| InChI | 1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13) | ||||
| InChIKey | MGFYIUFZLHCRTH-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 8758 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4H0W Bismuth bound human serum transferrin | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
VPDKTVRWCA
10 VSEHEATKCQ20 SFRDHMKSVI30 PSDGPSVACV40 KKASYLDCIR50 AIAANEADAV 60 TLDAGLVYDA70 YLAPNNLKPV80 VAEFYGSKED90 PQTFYYAVAV100 VKKDSGFQMN 110 QLRGKKSCHT120 GLGRSAGWNI130 PIGLLYCDLP140 EPRKPLEKAV150 ANFFSGSCAP 160 CADGTDFPQL170 CQLCPGCGCS180 TLNQYFGYSG190 AFKCLKDGAG200 DVAFVKHSTI 210 FENLANKADR220 DQYELLCLDN230 TRKPVDEYKD240 CHLAQVPSHT250 VVARSMGGKE 260 DLIWELLNQA270 QEHFGKDKSK280 EFQLFSSPHG290 KDLLFKDSAH300 GFLKVPPRMD 310 AKMYLGYEYV320 TAIRNLREGT330 CPEAPTDECK340 PVKWCALSHH350 ERLKCDEWSV 360 NSVGKIECVS370 AETTEDCIAK380 IMNGEADAMS390 LDGGFVYIAG400 KCGLVPVLAE 410 NYNKSDNCED420 TPEAGYFAIA430 VVKKSASDLT440 WDNLKGKKSC450 HTAVGRTAGW 460 NIPMGLLYNK470 INHCRFDEFF480 SEGCAPGSKK490 DSSLCKLCMG500 SGLNLCEPNN 510 KEGYYGYTGA520 FRCLVEKGDV530 AFVKHQTVPQ540 NTGGKNPDPW550 AKNLNEKDYE 560 LLCLDGTRKP570 VEEYANCHLA580 RAPNHAVVTR590 KDKEACVHKI600 LRQQQHLFGS 610 NVTDCSGNFC620 LFRSETKDLL630 FRDDTVCLAK640 LHDRNTYEKY650 LGEEYVKAVG 660 NLRKCSTSSL670 LEACTFRRP
|
|||||
|
|
||||||
| PDB ID: 5X5P Human serum transferrin bound to ruthenium NTA | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [2] |
| PDB Sequence |
DKTVRWCAVS
12 EHEATKCQSF22 RDHMKSVIPS32 DGPSVACVKK42 ASYLDCIRAI52 AANEADAVTL 62 DAGLVYDAYL72 APNNLKPVVA82 EFYGSKEDPQ92 TFYYAVAVVK102 KDSGFQMNQL 112 RGKKSCHTGL122 GRSAGWNIPI132 GLLYCDLPEP142 RKPLEKAVAN152 FFSGSCAPCA 162 DGTDFPQLCQ172 LCPGCGCSTL182 NQYFGYSGAF192 KCLKDGAGDV202 AFVKHSTIFE 212 NLANKADRDQ222 YELLCLDNTR232 KPVDEYKDCH242 LAQVPSHTVV252 ARSMGGKEDL 262 IWELLNQAQE272 HFGKDKSKEF282 QLFSSPHGKD292 LLFKDSAHGF302 LKVPPRMDAK 312 MYLGYEYVTA322 IRNLREGTCP332 CKPVKWCALS348 HHERLKCDEW358 SVNSVGKIEC 368 VSAETTEDCI378 AKIMNGEADA388 MSLDGGFVYI398 AGKCGLVPVL408 AENYNAGYFA 428 IAVVKKSASD438 LTWDNLKGKK448 SCHTAVGRTA458 GWNIPMGLLY468 NKINHCRFDE 478 FFSEGCAPGS488 KKDSSLCKLC498 MGSGLNLCEP508 NNKEGYYGYT518 GAFRCLVEKG 528 DVAFVKHQTV538 PQNTGGKNPD548 PWAKNLNEKD558 YELLCLDGTR568 KPVEEYANCH 578 LARAPNHAVV588 TRKDKEACVH598 KILRQQQHLF608 GSNSETKDLL630 FRDDTVCLAK 640 LHDRNTYEKY650 LGEEYVKAVG660 NLRKCSTSSL670 LEACTFRRP
|
|||||
|
|
||||||
| PDB ID: 7FFM Human serum transferrin with five osmium binding sites | ||||||
| Method | X-ray diffraction | Resolution | 3.06 Å | Mutation | Yes | [2] |
| PDB Sequence |
DKTVRWCAVS
12 EHEATKCQSF22 RDHMKSVIPS32 DGPSVACVKK42 ASYLDCIRAI52 AANEADAVTL 62 DAGLVYDAYL72 APNNLKPVVA82 EFYGSKEDPQ92 TFYYAVAVVK102 KDSGFQMNQL 112 RGKKSCHTGL122 GRSAGWNIPI132 GLLYCDLPEP142 RKPLEKAVAN152 FFSGSCAPCA 162 DGTDFPQLCQ172 LCPGCGCSTL182 NQYFGYSGAF192 KCLKDGAGDV202 AFVKHSTIFE 212 NLANKADRDQ222 YELLCLDNTR232 KPVDEYKDCH242 LAQVPSHTVV252 ARSMGGKEDL 262 IWELLNQAQE272 HFGKDKSKEF282 QLFSSPHGKD292 LLFKDSAHGF302 LKVPPRMDAK 312 MYLGYEYVTA322 IRNLREGTCP332 CKPVKWCALS348 HHERLKCDEW358 SVNSVGKIEC 368 VSAETTEDCI378 AKIMNGEADA388 MSLDGGFVYI398 AGKCGLVPVL408 AENYNAGYFA 428 VAVVKKSASD438 LTWDNLKGKK448 SCHTAVGRTA458 GWNIPMGLLY468 NKINHCRFDE 478 FFSEGCAPGS488 KKDSSLCKLC498 MGSGLNLCEP508 NNKEGYYGYT518 GAFRCLVEKG 528 DVAFVKHQTV538 PQNTGGKNPD548 PWAKNLNEKD558 YELLCLDGTR568 KPVEEYANCH 578 LARAPNHAVV588 TRKDKEACVH598 KILRQQQHLF608 GSNSETKDLL630 FRDDTVCLAK 640 LHDRNTYEKY650 LGEEYVKAVG660 NLRKCSTSSL670 LEACTFRRP
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. | ||||
| REF 2 | Binding of ruthenium and osmium at non?iron sites of transferrin accounts for their iron-independent cellular uptake. J Inorg Biochem. 2022 Sep;234:111885. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.