Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T13017 Target Info
Target Name Syndecan-1 (SDC1)
Synonyms SYND1; SDC; CD138
Target Type Clinical trial Target
Gene Name SDC1
Biochemical Class Peptide translocating syndecan
UniProt ID
SDC1_HUMAN
Ligand General Information  Top
Ligand Name 5-(Dimethylamino)naphthalene-1-sulfonic acid Ligand Info
Canonical SMILES CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)O
InChI 1S/C12H13NO3S/c1-13(2)11-7-3-6-10-9(11)5-4-8-12(10)17(14,15)16/h3-8H,1-2H3,(H,14,15,16)
InChIKey BBEQQKBWUHCIOU-UHFFFAOYSA-N
PubChem Compound ID 1792
Drug Binding Sites of Target  Top
PDB ID: 4GVC      Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide
Method X-ray diffraction Resolution 1.54 Å Mutation No [1]
PDB Sequence
TKQEEFA
Residue
Distance (Å)
THR1
1.769
Residue
Distance (Å)
LYS2
3.873
PDB ID: 4GVD      Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with Syndecan1 Peptide
Method X-ray diffraction Resolution 1.85 Å Mutation No [1]
PDB Sequence
TKQEEFYA
Residue
Distance (Å)
THR1
1.860
Residue
Distance (Å)
LYS2
3.756
References  Top
REF 1 The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure. 2013 Mar 5;21(3):342-54.

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