Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22118 | Target Info | |||
| Target Name | Dopamine D1 receptor (D1R) | ||||
| Synonyms | D(1A) dopamine receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | DRD1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Dopamine | Ligand Info | |||
| Canonical SMILES | C1=CC(=C(C=C1CCN)O)O | ||||
| InChI | 1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | ||||
| InChIKey | VYFYYTLLBUKUHU-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 681 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7CKZ Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
FSVRILTACF
29 LSLLILSTLL39 GNTLVCAAVI49 RFRHLRSKVT59 NFFVISLAVS69 DLLVAVLVMP 79 WKAVAEIAGF89 WPFGSFCNIW99 VAFDIMCSTA109 SILNLCVISV119 DRYWAISSPF 129 RYERKMTPKA139 AFILISVAWT149 LSVLISFIPV159 QLSWHKANCD187 SSLSRTYAIS 197 SSVISFYIPV207 AIMIVTYTRI217 YRIAQKQIRR227 IAALERAAVH237 SFKRETKVLK 272 TLSVIMGVFV282 CCWLPFFILN292 CILPFCFCID309 SNTFDVFVWF319 GWANSSLNPI 329 IYAFNADFRK339 AFSTL
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| PDB ID: 7X2F Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
SVRILTACFL
30 SLLILSTLLG40 NTLVCAAVIR50 FRHLRSKVTN60 FFVISLAVSD70 LLVAVLVMPW 80 KAVAEIAGFW90 PFGSFCNIWV100 AFDIMCSTAS110 ILNLCVISVD120 RYWAISSPFR 130 YERKMTPKAA140 FILISVAWTL150 SVLISFIPVQ160 LSWHKAKDNC186 DSSLSRTYAI 196 SSSVISFYIP206 VAIMIVTYTR216 IYRIAQKQIR226 RIAALERAAV236 HAKNCFKRET 268 KVLKTLSVIM278 GVFVCCWLPF288 FILNCILPFC298 GFCIDSNTFD314 VFVWFGWANS 324 SLNPIIYAFN334 ADFRKAFSTL344 LG
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| PDB ID: 7F0T Cryo-EM structure of dopamine receptor 1 and mini-Gs complex with dopamine bound | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [3] |
| PDB Sequence |
SVRILTACFL
30 SLLILSTLLG40 NTLVCAAVIR50 FRHLRSKVTN60 FFVISLAVSD70 LLVAVLVMPW 80 KAVAEIAGFW90 PFGSFCNIWV100 AFDIMCSTAS110 ILNLCVISVD120 RYWAISSPFR 130 YERKMTPKAA140 FILISVAWTL150 SVLISFIPVQ160 LSWHKAKDNC186 DSSLSRTYAI 196 SSSVISFYIP206 VAIMIVTYTR216 IYRIAQKQIR226 RIAALERAAV236 HAKNCFKRET 268 KVLKTLSVIM278 GVFVCCWLPF288 FILNCILPFC298 GFCIDSNTFD314 VFVWFGWANS 324 SLNPIIYAFN334 ADFRKAFSTL344 LG
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| PDB ID: 7F1O Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex with Nb35 | ||||||
| Method | Electron microscopy | Resolution | 3.13 Å | Mutation | Yes | [3] |
| PDB Sequence |
FSVRILTACF
29 LSLLILSTLL39 GNTLVCAAVI49 RFRHLRSKVT59 NFFVISLAVS69 DLLVAVLVMP 79 WKAVAEIAGF89 WPFGSFCNIW99 VAFDIMCSTA109 SILNLCVISV119 DRYWAISSPF 129 RYERKMTPKA139 AFILISVAWT149 LSVLISFIPV159 QLSWHKANCD187 SSLSRTYAIS 197 SSVISFYIPV207 AIMIVTYTRI217 YRIAQKQIRR227 IAALERAAVH237 FKRETKVLKT 273 LSVIMGVFVC283 CWLPFFILNC293 ILPFCGFCID309 SNTFDVFVWF319 GWANSSLNPI 329 IYAFNADFRK339 AFSTLLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LDP or .LDP2 or .LDP3 or :3LDP;style chemicals stick;color identity;select .F:103 or .F:104 or .F:107 or .F:108 or .F:190 or .F:194 or .F:195 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:317 or .F:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7F1Z Cryo-EM structure of the GDP-bound dopamine receptor 1 and mini-Gs complex without Nb35 | ||||||
| Method | Electron microscopy | Resolution | 3.46 Å | Mutation | Yes | [3] |
| PDB Sequence |
FSVRILTACF
29 LSLLILSTLL39 GNTLVCAAVI49 RFRHLRSKVT59 NFFVISLAVS69 DLLVAVLVMP 79 WKAVAEIAGF89 WPFGSFCNIW99 VAFDIMCSTA109 SILNLCVISV119 DRYWAISSPF 129 RYERKMTPKA139 AFILISVAWT149 LSVLISFIPV159 QLSWHKANCD187 SSLSRTYAIS 197 SSVISFYIPV207 AIMIVTYTRI217 YRIAQKQIRR227 IAALERAAVH237 FKRETKVLKT 273 LSVIMGVFVC283 CWLPFFILNC293 ILPFCGFCID309 SNTFDVFVWF319 GWANSSLNPI 329 IYAFNADFRK339 AFSTLLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LDP or .LDP2 or .LDP3 or :3LDP;style chemicals stick;color identity;select .F:103 or .F:104 or .F:107 or .F:108 or .F:190 or .F:194 or .F:195 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:317 or .F:321; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7F23 Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex with Nb35 | ||||||
| Method | Electron microscopy | Resolution | 3.58 Å | Mutation | Yes | [3] |
| PDB Sequence |
FSVRILTACF
29 LSLLILSTLL39 GNTLVCAAVI49 RFRHLRSKVT59 NFFVISLAVS69 DLLVAVLVMP 79 WKAVAEIAGF89 WPFGSFCNIW99 VAFDIMCSTA109 SILNLCVISV119 DRYWAISSPF 129 RYERKMTPKA139 AFILISVAWT149 LSVLISFIPV159 QLSWHKANCD187 SSLSRTYAIS 197 SSVISFYIPV207 AIMIVTYTRI217 YRIAQKQIRR227 IAALERAAVH237 FKRETKVLKT 273 LSVIMGVFVC283 CWLPFFILNC293 ILPFCGCIDS310 NTFDVFVWFG320 WANSSLNPII 330 YAFNADFRKA340 FSTLLG
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LDP or .LDP2 or .LDP3 or :3LDP;style chemicals stick;color identity;select .F:103 or .F:104 or .F:107 or .F:108 or .F:190 or .F:194 or .F:195 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:317 or .F:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 7F24 Cryo-EM structure of the GTP-bound dopamine receptor 1 and mini-Gs complex without Nb35 | ||||||
| Method | Electron microscopy | Resolution | 4.16 Å | Mutation | Yes | [3] |
| PDB Sequence |
FSVRILTACF
29 LSLLILSTLL39 GNTLVCAAVI49 RFRHLRSKVT59 NFFVISLAVS69 DLLVAVLVMP 79 WKAVAEIAGF89 WPFGSFCNIW99 VAFDIMCSTA109 SILNLCVISV119 DRYWAISSPF 129 RYERKMTPKA139 AFILISVAWT149 LSVLISFIPV159 QLSWHKANCD187 SSLSRTYAIS 197 SSVISFYIPV207 AIMIVTYTRI217 YRIAQKQIRR227 IAALERAAVH237 FKRETKVLKT 273 LSVIMGVFVC283 CWLPFFILNC293 ILPFCGFCID309 SNTFDVFVWF319 GWANSSLNPI 329 IYAFNADFRK339 AFSTLLG
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LDP or .LDP2 or .LDP3 or :3LDP;style chemicals stick;color identity;select .F:103 or .F:104 or .F:107 or .F:108 or .F:194 or .F:195 or .F:198 or .F:199 or .F:202 or .F:285 or .F:288 or .F:289 or .F:292 or .F:317 or .F:321; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 7LJD Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [4] |
| PDB Sequence |
SVRILTACFL
30 SLLILSTLLG40 NTLVCAAVIR50 FRHLRSKVTN60 FFVISLAVSD70 LLVAVLVMPW 80 KAVAEIAGFW90 PFGSFCNIWV100 AFDIMCSTAS110 ILNLCVISVD120 RYWAISSPFR 130 YERKMTPKAA140 FILISVAWTL150 SVLISFIPVQ160 LSWHKAKPID184 NCDSSLSRTY 194 AISSSVISFY204 IPVAIMIVTY214 TRIYRIAQKQ224 IRRIAALERA234 AVHAKNCQFK 265 RETKVLKTLS275 VIMGVFVCCW285 LPFFILNCIL295 PFCCIDSNTF313 DVFVWFGWAN 323 SSLNPIIYAF333 NADFRKAFST343 LLGCY
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LDP or .LDP2 or .LDP3 or :3LDP;style chemicals stick;color identity;select .R:103 or .R:104 or .R:107 or .R:108 or .R:190 or .R:195 or .R:198 or .R:199 or .R:202 or .R:285 or .R:288 or .R:289 or .R:292 or .R:317 or .R:321; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18. | ||||
| REF 2 | Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun. 2022 Jun 8;13(1):3186. | ||||
| REF 3 | Structural insights into G protein activation by D1 dopamine receptor. Sci Adv. 2022 Jun 10;8(23):eabo4158. | ||||
| REF 4 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res. 2021 May;31(5):593-596. | ||||
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