Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22118 | Target Info | |||
| Target Name | Dopamine D1 receptor (D1R) | ||||
| Synonyms | D(1A) dopamine receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | DRD1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | Ligand Info | |||
| Canonical SMILES | C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3 | ||||
| InChI | 1S/C16H16ClNO2/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H2/t13-/m1/s1 | ||||
| InChIKey | GHWJEDJMOVUXEC-CYBMUJFWSA-N | ||||
| PubChem Compound ID | 12668019 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7JV5 Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
SVRILTACFL
30 SLLILSTLLG40 NTLVCAAVIR50 FRHLRSKVTN60 FFVISLAVSD70 LLVAVLVMPW 80 KAVAEIAGFW90 PFGSFCNIWV100 AFDIMCSTAS110 ILNLCVISVD120 RYWAISSPFR 130 YERKMTPKAA140 FILISVAWTL150 SVLISFIPVQ160 LSWHKAKPNC186 DSSLSRTYAI 196 SSSVISFYIP206 VAIMIVTYTR216 IYRIAQKQIR226 RIAALERAAV236 HAKNSFKRET 268 KVLKTLSVIM278 GVFVCCWLPF288 FILNCILPFC298 CIDSNTFDVF316 VWFGWANSSL 326 NPIIYAFNAD336 FRKAFSTLLG346 CY
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| PDB ID: 7LJC Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [2] |
| PDB Sequence |
SVRILTACFL
30 SLLILSTLLG40 NTLVCAAVIR50 FRHLRSKVTN60 FFVISLAVSD70 LLVAVLVMPW 80 KAVAEIAGFW90 PFGSFCNIWV100 AFDIMCSTAS110 ILNLCVISVD120 RYWAISSPFR 130 YERKMTPKAA140 FILISVAWTL150 SVLISFIPVQ160 LSWHKAKPNC186 DSSLSRTYAI 196 SSSVISFYIP206 VAIMIVTYTR216 IYRIAQKQIR226 RIAALERAAV236 HAKNFKRETK 269 VLKTLSVIMG279 VFVCCWLPFF289 ILNCILPFCC307 IDSNTFDVFV317 WFGWANSSLN 327 PIIYAFNADF337 RKAFSTLLGC347
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021 Feb 18;184(4):931-942.e18. | ||||
| REF 2 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell Res. 2021 May;31(5):593-596. | ||||
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