Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31721 | Target Info | |||
| Target Name | Excitatory amino acid transporter 3 (SLC1A1) | ||||
| Synonyms | Solute carrier family 1 member 1; Sodium-dependent glutamate/aspartate transporter 3; Neuronal and epithelial glutamate transporter; Excitatory amino-acid carrier 1; EAAT3; EAAC1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A1 | ||||
| Biochemical Class | Dicarboxylate/amino acid:cation symporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-aspartic acid | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)C(=O)O | ||||
| InChI | 1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1 | ||||
| InChIKey | CKLJMWTZIZZHCS-REOHCLBHSA-N | ||||
| PubChem Compound ID | 5960 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6X2Z hEAAT3-OFS-Asp | ||||||
| Method | Electron microscopy | Resolution | 3.03 Å | Mutation | Yes | [1] |
| PDB Sequence |
KNNWVLLSTV
25 AAVVLGITTG35 VLVREHSNLS45 TLEKFYFAFP55 GEILMRMLKL65 IILPLIISSM 75 ITGVAALDSN85 VSGKIGLRAV95 VYYFCTTLIA105 VILGIVLVVS115 IKPGVTQKVG 125 STVDAMLDLI146 RNMFPENLVQ156 ACFQQYKTKR166 EEEYKIVGMY206 SDGINVLGLI 216 VFCLVFGLVI226 GKMGEKGQIL236 VDFFNALSDA246 TMKIVQIIMC256 YMPLGILFLI 266 AGKIIEVEDW276 EIFRKLGLYM286 ATVLTGLAIH296 SIVILPLIYF306 IVVRKNPFRF 316 AMGMAQALLT326 ALMISSSSAT336 LPVTFRCAEE346 NNQVDKRITR356 FVLPVGATIN 366 MDGTALYEAV376 AAVFIAQLND386 LDLGIGQIIT396 ISITATSASI406 GAAGVPQAGL 416 VTMVIVLSAV426 GLPAEDVTLI436 IAVDWLLDRF446 RTMVNVLGDA456 FGTGIVEKLS 466 KKELEQMDV
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| PDB ID: 6X3E hEAAT3-Asymmetric-1o2i | ||||||
| Method | Electron microscopy | Resolution | 3.42 Å | Mutation | No | [1] |
| PDB Sequence |
KNNWVLLSTV
25 AAVVLGITTG35 VLVREHSNLS45 TLEKFYFAFP55 GEILMRMLKL65 IILPLIISSM 75 ITGVAALDSN85 VSGKIGLRAV95 VYYFCTTLIA105 VILGIVLVVS115 IKPGVTQKVG 125 STVDAMLDLI146 RNMFPENLVQ156 ACFQQYKTKR166 EEEYKIVGMY206 SDGINVLGLI 216 VFCLVFGLVI226 GKMGEKGQIL236 VDFFNALSDA246 TMKIVQIIMC256 YMPLGILFLI 266 AGKIIEVEDW276 EIFRKLGLYM286 ATVLTGLAIH296 SIVILPLIYF306 IVVRKNPFRF 316 AMGMAQALLT326 ALMISSSSAT336 LPVTFRCAEE346 NNQVDKRITR356 FVLPVGATIN 366 MDGTALYEAV376 AAVFIAQLND386 LDLGIGQIIT396 ISITATSASI406 GAAGVPQAGL 416 VTMVIVLSAV426 GLPAEDVTLI436 IAVDWLLDRF446 RTMVNVLGDA456 FGTGIVEKLS 466 KKELEQMDV
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv. 2021 Mar 3;7(10):eabf5814. | ||||
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