Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T48598 | Target Info | |||
Target Name | GTPase KRas (KRAS) | ||||
Synonyms | c-Ki-ras; c-K-ras; RASK2; Ki-Ras; KRAS2; K-Ras 2 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | KRAS | ||||
Biochemical Class | Small GTPase | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | (2R,4S)-4-[(5-bromo-1H-indole-3-carbonyl)amino]-2-[(4-chlorophenyl)methyl]piperidin-1-ium | Ligand Info | |||
Canonical SMILES | C1C[NH2+]C(CC1NC(=O)C2=CNC3=C2C=C(C=C3)Br)CC4=CC=C(C=C4)Cl | ||||
InChI | 1S/C21H21BrClN3O/c22-14-3-6-20-18(10-14)19(12-25-20)21(27)26-16-7-8-24-17(11-16)9-13-1-4-15(23)5-2-13/h1-6,10,12,16-17,24-25H,7-9,11H2,(H,26,27)/p+1/t16-,17+/m0/s1 | ||||
InChIKey | GGXKHDYKPGTZBA-DLBZAZTESA-O | ||||
PubChem Compound ID | 134812652 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 6CC9 NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | ||||||
Method | Solution NMR | Resolution | N.A. | Mutation | Yes | [1] |
PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHHYREQI100 KRVKDSEDVP 110 MVLVGNKCDL120 PSRTVDTKQA130 QDLARSYGIP140 FIETSAKTRQ150 GVDDAFYTLV 160 REIRKHKEKM170 SKDGKKKKKK180 SKTKC
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PDB ID: 6CCX NMR data-driven model of GTPase KRas-GMPPNP:Cmpd2 complex tethered to a nanodisc | ||||||
Method | Solution NMR | Resolution | N.A. | Mutation | Yes | [1] |
PDB Sequence |
MTEYKLVVVG
10 AVGVGKSALT20 IQLIQNHFVD30 EYDPTIEDSY40 RKQVVIDGET50 CLLDILDTAG 60 QEEYSAMRDQ70 YMRTGEGFLC80 VFAINNTKSF90 EDIHHYREQI100 KRVKDSEDVP 110 MVLVGNKCDL120 PSRTVDTKQA130 QDLARSYGIP140 FIETSAKTRQ150 GVDDAFYTLV 160 REIRKHKEKM170 SKDGKKKKKK180 SKTKC
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References | Top | ||||
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REF 1 | Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site. Cell Chem Biol. 2018 Nov 15;25(11):1327-1336.e4. |
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