Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T48598 Target Info
Target Name GTPase KRas (KRAS)
Synonyms c-Ki-ras; c-K-ras; RASK2; Ki-Ras; KRAS2; K-Ras 2
Target Type Clinical trial Target
Gene Name KRAS
Biochemical Class Small GTPase
UniProt ID
RASK_HUMAN
Ligand General Information  Top
Ligand Name Geran-8-YL geran Ligand Info
Canonical SMILES CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
InChI 1S/C20H34/c1-7-18(4)12-9-14-20(6)16-10-15-19(5)13-8-11-17(2)3/h7,11,14-15H,8-10,12-13,16H2,1-6H3/b18-7+,19-15+,20-14+
InChIKey HSOYJGBJQAKCNA-CAIKYXSQSA-N
PubChem Compound ID 446073
Drug Binding Sites of Target  Top
PDB ID: 1N4S      Protein Geranylgeranyltransferase type-I Complexed with GGPP and a Geranylgeranylated KKKSKTKCVIL Peptide Product
Method X-ray diffraction Resolution 2.60 Å Mutation No [1]
PDB Sequence
CVIL
Residue
Distance (Å)
CYS108
1.819
VAL109
3.099
Residue
Distance (Å)
ILE110
3.569
LEU111
4.657
PDB ID: 1N4P      Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate
Method X-ray diffraction Resolution 2.65 Å Mutation No [1]
PDB Sequence
CVIL
Residue
Distance (Å)
CYS508
1.817
VAL509
3.168
Residue
Distance (Å)
ILE510
3.750
LEU511
4.772
PDB ID: 1N4R      Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product
Method X-ray diffraction Resolution 2.80 Å Mutation No [1]
PDB Sequence
TKCVIL
Residue
Distance (Å)
CYS108
1.815
VAL109
3.990
Residue
Distance (Å)
ILE110
3.561
LEU111
4.209
References  Top
REF 1 Structure of mammalian protein geranylgeranyltransferase type-I. EMBO J. 2003 Nov 17;22(22):5963-74.

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