Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59328 | Target Info | |||
| Target Name | Epidermal growth factor receptor (EGFR) | ||||
| Synonyms | Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB | ||||
| Target Type | Successful Target | ||||
| Gene Name | EGFR | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Alpha-D-Mannose | Ligand Info | |||
| Canonical SMILES | C(C1C(C(C(C(O1)O)O)O)O)O | ||||
| InChI | 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1 | ||||
| InChIKey | WQZGKKKJIJFFOK-PQMKYFCFSA-N | ||||
| PubChem Compound ID | 185698 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7LFR Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | Yes | [1] |
| PDB Sequence |
EKKVCQGTSN
12 KLTQLGTFED22 HFLSLQRMFN32 NCEVVLGNLE42 ITYVQRNYDL52 SFLKTIQEVA 62 GYVLIALNTV72 ERIPLENLQI82 IKGNMYYENS92 YALAVLSNYD102 ANKTGLKELP 112 MRNLQEILHG122 AVRFSNNPAL132 CNVESIQWRD142 IVSSDFLSNM152 SMDFQNHLGS 162 CQKCDPSCPN172 GSCWGAGEEN182 CQKLTKIICA192 QQCSGRCRGK202 SPSDCCHNQC 212 AAGCTGPRES222 DCLVCRKFRD232 EATCKDTCPP242 LMLYNPTTYQ252 MDVNPEGKYS 262 FGATCVKKCP272 RNYVVTDHGS282 CVRACGADSY292 EMEEDGVRKC302 KKCEGPCRKV 312 CNGIGIGEFK322 DSLSINATNI332 KHFKNCTSIS342 GDLHILPVAF352 RGDSFTHTPP 362 LDPQELDILK372 TVKEITGFLL382 IQAWPENRTD392 LHAFENLEII402 RGRTKQHGQF 412 SLAVVSLNIT422 SLGLRSLKEI432 SDGDVIISGN442 KNLCYANTIN452 WKKLFGTSGQ 462 KTKIISNRGE472 NSCKATGQVC482 HALCSPEGCW492 GPEPRDCVSH502 |
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| PDB ID: 3C09 Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [2] |
| PDB Sequence |
KKVCNGIGIG
319 EFKDSLSINA329 TNIKHFKNCT339 SISGDLHILP349 VAFRGDSFTH359 TPPLDPQELD 369 ILKTVKEITG379 FLLIQAWPEN389 RTDLHAFENL399 EIIRGRTKQH409 GQFSLAVVSL 419 NITSLGLRSL429 KEISDGDVII439 SGNKNLCYAN449 TINWKKLFGT459 SGQKTKIISN 469 RGENSCKATG479 QVCHALCSPE489 GCWGPEPRDC499 V
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature. 2022 Feb;602(7897):518-522. | ||||
| REF 2 | Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. | ||||
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