Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62431 | Target Info | |||
| Target Name | Tyrosine-protein kinase SYK (SYK) | ||||
| Synonyms | p72-Syk; Spleen tyrosine kinase | ||||
| Target Type | Successful Target | ||||
| Gene Name | SYK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | AMP-PNP | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N | ||||
| InChI | 1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | PVKSNHVPLWYQGJ-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 33113 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4FL3 Structural and Biophysical Characterization of the Syk Activation Switch | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
SANHLPFFFG
18 NITREEAEDY28 LVQGGMSDGL38 YLLRQSRNYL48 GGFALSVAHG58 RKAHHYTIER 68 ELNGTYAIAG78 GRTHASPADL88 CHYHSQESDG98 LVCLLKKPFN108 RPQGVQPKTG 118 PFEDLKENLI128 REYVKQTWNL138 QGQALEQAII148 SQKPQLEKLI158 ATTAHEKMPW 168 FHGKISREES178 EQIVLIGSKT188 NGKFLIRARD198 NNGSYALCLL208 HEGKVLHYRI 218 DKDKTGKLSI228 PEGKKFDTLW238 QLVEHYSYKA248 DGLLRVLTVP258 CQKREALPMD 344 TEVFESPFAD354 PEEIRPKEVY364 LDRKLLTLED374 KELGSGNFGT384 VKKGYYQMKK 394 VVKTVAVKIL404 KNEANDPALK414 DELLAEANVM424 QQLDNPYIVR434 MIGICEAESW 444 MLVMEMAELG454 PLNKYLQQNR464 HVKDKNIIEL474 VHQVSMGMKY484 LEESNFVHRD 494 LAARNVLLVT504 QHYAKISDFG514 LSKALRAPVK537 WYAPECINYY547 KFSSKSDVWS 557 FGVLMWEAFS567 YGQKPYRGMK577 GSEVTAMLEK587 GERMGCPAGC597 PREMYDLMNL 607 CWTYDVENRP617 GFAAVELRLR627 NYYYDVVN
|
|||||
|
|
LEU377
3.790
GLY378
4.003
SER379
3.595
GLY380
3.305
ASN381
2.702
PHE382
3.856
GLY383
3.631
VAL385
3.556
ALA400
3.344
LYS402
2.719
VAL433
3.512
MET448
3.747
|
|||||
| PDB ID: 4FL2 Structural and Biophysical Characterization of the Syk Activation Switch | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [1] |
| PDB Sequence |
SANHLPFFFG
18 NITREEAEDY28 LVQGGMSDGL38 YLLRQSRNYL48 GGFALSVAHG58 RKAHHYTIER 68 ELNGTYAIAG78 GRTHASPADL88 CHYHSQESDG98 LVCLLKKPFN108 RPQGVQPKTG 118 PFEDLKENLI128 REYVKQTWNL138 QGQALEQAII148 SQKPQLEKLI158 ATTAHEKMPW 168 FHGKISREES178 EQIVLIGSKT188 NGKFLIRARD198 NNGSYALCLL208 HEGKVLHYRI 218 DKDKTGKLSI228 PEGKKFDTLW238 QLVEHYSYKA248 DGLLRVLTVP258 CQKIGTQREA 340 LPMDTEVYES350 PYADPEEIRP360 KEVYLDRKLL370 TLEDKELGSG380 NFGTVKKGYY 390 QMKKVVKTVA400 VKILKNEAND410 PALKDELLAE420 ANVMQQLDNP430 YIVRMIGICE 440 AESWMLVMEM450 AELGPLNKYL460 QQNRHVKDKN470 IIELVHQVSM480 GMKYLEESNF 490 VHRDLAARNV500 LLVTQHYAKI510 SDFGLSKALR520 ADENYYKAQT530 HGKWPVKWYA 540 PECINYYKFS550 SKSDVWSFGV560 LMWEAFSYGQ570 KPYRGMKGSE580 VTAMLEKGER 590 MGCPAGCPRE600 MYDLMNLCWT610 YDVENRPGFA620 AVELRLRNYY630 YDVVN |
|||||
|
|
LEU377
3.846
GLY378
3.864
SER379
3.482
GLY380
3.294
ASN381
2.678
PHE382
3.674
GLY383
3.644
VAL385
3.514
ALA400
3.309
LYS402
2.791
VAL433
3.644
MET448
3.793
GLU449
2.890
|
|||||
| PDB ID: 4FL1 Structural and Biophysical Characterization of the Syk Activation Switch | ||||||
| Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | No | [1] |
| PDB Sequence |
VYLDRKLLTL
372 EDKELGSGNF382 GTVKKGYYQM392 KKVVKTVAVK402 ILKPALKDEL417 LAEANVMQQL 427 DNPYIVRMIG437 ICEAESWMLV447 MEMAELGPLN457 KYLQQNRHVK467 DKNIIELVHQ 477 VSMGMKYLEE487 SNFVHRDLAA497 RNVLLVTQHY507 AKISDFGLSK517 ALRADENYYK 527 AQTHGKWPVK537 WYAPECINYY547 KFSSKSDVWS557 FGVLMWEAFS567 YGQKPYRGMK 577 GSEVTAMLEK587 GERMGCPAGC597 PREMYDLMNL607 CWTYDVENRP617 GFAAVELRLR 627 NYYYDVVN
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural and biophysical characterization of the Syk activation switch. J Mol Biol. 2013 Jan 23;425(2):309-33. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.