Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78181 | Target Info | |||
| Target Name | MTOR complex 2 (RICTOR) | ||||
| Synonyms | hAVO3; Rapamycin-insensitive companion of mTOR; KIAA1999; AVO3 homolog | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | RICTOR | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Phosphothiophosphoric acid-adenylate ester | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=S)(O)O)O)O)N | ||||
| InChI | 1S/C10H16N5O12P3S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | NLTUCYMLOPLUHL-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 440317 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6ZWO cryo-EM structure of human mTOR complex 2, focused on one half | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
NVPLDLTREP
34 SDNLREILQN44 VARLQGVSNM54 RKLGHLNNFT64 KLLCDIGHSE74 EKLGFHYEDI 84 IICLRLALLN94 EAKEVRAAGL104 RALRYLIQDS114 SILQKVLKLK124 VDYLIARCID 134 IQQSNEVERT144 QALRLVRKMI154 TVNASLFPSS164 VTNSLIAVGN174 DGLQERDRMV 184 RACIAIICEL194 ALQNPEVVAL204 RGGLNTILKN214 VIDCQLSRIN224 EALITTILHL 234 LNHPKTRQYV244 RADVELERIL254 APYTDFHYRH264 SPDTAEGQLK274 EDREARFLAS 284 KMGIIATFRS294 WAGIINLCKP304 GNSGIQSLIG314 VLCIPNMEIR324 RGLLEVLYDI 334 FRLPLPVVTE344 EFIEALLSVD354 PGRFQDSWRL364 SDGFVAAEAK374 TILPHRARSR 384 PDLMDNYLAL394 ILSAFIRNGL404 LEGLVEVITN414 SDDHISVRAT424 ILLGELLHMA 434 NTILPHSHSH444 HLHCLPTLMN454 MAASFDIPKE464 KRLRASAALN474 CLKRFHEMKK 484 RGPKPYSLHL494 DHIIQKAIAT504 HQKRDQILKD523 TEEALLINLR533 DSQVLQHKEN 543 LEWNWNLIGT553 ILKWPNVNLR563 NYKDEQLHRF573 VRRLLYFYKP583 SSKLYANLDL 593 DFAKAKQLTV603 VGCQFTEFLL613 ESEEDGQGYL623 EDLVKDIVQW633 LNASSGMKPE 643 RSLQNNGLLT653 TLSQHYFLFI663 GTLSCHPHGV673 KMLEKCSVFQ683 CLLNLCSLKN 693 QDHLLKLTVS703 SLDYSRDGLA713 RVILSKILTA723 ATDACRLYAT733 KHLRVLLRAN 743 VEFFNNWGIE753 LLVTQLHDKN763 KTISSEALDI773 LDEACEDKAN783 LHALIQMKPA 793 LSHLGDKGLL803 LLLRFLSIPK813 GFSYLNERGY823 VAKQLEKWHR833 EYNSKYVDLI 843 EEQLNEALTT853 YRKPQRPHVY877 LPIHLYGQLV887 HHKTGCHLLE897 VQNIITELCR 907 NVRTPDLDKW917 EEIKKLKASL927 WALGNIGSSN937 WGLNLLQEEN947 VIPDILKLAK 957 QCEVLSIRGT967 CVYVLGLIAK977 TKQGCDILKC987 HNWDAVRHSR997 KHLWPVVPDY 1424 IGLALPVDIN1434 DIFQVKDIPY1444 FQTKSFHLLR1484 QQMSLTEIMN1494 TGLQEHTDDN 1519 CLYCVCIEIL1529 GFQPSNQLSM1607 CRILLRKEVL1617 RLVINLSSSV1627 STKCHETGLL 1637 TIKEKYPQTF1647 DDICLYSEVS1657 HLLSHCTFRL1667 PCRRFIQELF1677 QDVQFLQMHE 1687 EAEAVLA
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| PDB ID: 6ZWM cryo-EM structure of human mTOR complex 2, overall refinement | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
NVPLDLTREP
34 SDNLREILQN44 VARLQGVSNM54 RKLGHLNNFT64 KLLCDIGHSE74 EKLGFHYEDI 84 IICLRLALLN94 EAKEVRAAGL104 RALRYLIQDS114 SILQKVLKLK124 VDYLIARCID 134 IQQSNEVERT144 QALRLVRKMI154 TVNASLFPSS164 VTNSLIAVGN174 DGLQERDRMV 184 RACIAIICEL194 ALQNPEVVAL204 RGGLNTILKN214 VIDCQLSRIN224 EALITTILHL 234 LNHPKTRQYV244 RADVELERIL254 APYTDFHYRH264 SPDTAEGQLK274 EDREARFLAS 284 KMGIIATFRS294 WAGIINLCKP304 GNSGIQSLIG314 VLCIPNMEIR324 RGLLEVLYDI 334 FRLPLPVVTE344 EFIEALLSVD354 PGRFQDSWRL364 SDGFVAAEAK374 TILPHRARSR 384 PDLMDNYLAL394 ILSAFIRNGL404 LEGLVEVITN414 SDDHISVRAT424 ILLGELLHMA 434 NTILPHSHSH444 HLHCLPTLMN454 MAASFDIPKE464 KRLRASAALN474 CLKRFHEMKK 484 RGPKPYSLHL494 DHIIQKAIAT504 HQKRDQILKD523 TEEALLINLR533 DSQVLQHKEN 543 LEWNWNLIGT553 ILKWPNVNLR563 NYKDEQLHRF573 VRRLLYFYKP583 SSKLYANLDL 593 DFAKAKQLTV603 VGCQFTEFLL613 ESEEDGQGYL623 EDLVKDIVQW633 LNASSGMKPE 643 RSLQNNGLLT653 TLSQHYFLFI663 GTLSCHPHGV673 KMLEKCSVFQ683 CLLNLCSLKN 693 QDHLLKLTVS703 SLDYSRDGLA713 RVILSKILTA723 ATDACRLYAT733 KHLRVLLRAN 743 VEFFNNWGIE753 LLVTQLHDKN763 KTISSEALDI773 LDEACEDKAN783 LHALIQMKPA 793 LSHLGDKGLL803 LLLRFLSIPK813 GFSYLNERGY823 VAKQLEKWHR833 EYNSKYVDLI 843 EEQLNEALTT853 YRKPQRPHVY877 LPIHLYGQLV887 HHKTGCHLLE897 VQNIITELCR 907 NVRTPDLDKW917 EEIKKLKASL927 WALGNIGSSN937 WGLNLLQEEN947 VIPDILKLAK 957 QCEVLSIRGT967 CVYVLGLIAK977 TKQGCDILKC987 HNWDAVRHSR997 KHLWPVVPDY 1424 IGLALPVDIN1434 DIFQVKDIPY1444 FQTKSFHLLR1484 QQMSLTEIMN1494 TGLQEHTDDN 1519 CLYCVCIEIL1529 GFQPSNQLSM1607 CRILLRKEVL1617 RLVINLSSSV1627 STKCHETGLL 1637 TIKEKYPQTF1647 DDICLYSEVS1657 HLLSHCTFRL1667 PCRRFIQELF1677 QDVQFLQMHE 1687 EAEAVLA
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The 3.2-? resolution structure of human mTORC2. Sci Adv. 2020 Nov 6;6(45):eabc1251. | ||||
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