Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94444 | Target Info | |||
| Target Name | Aldehyde oxidase (AOX1) | ||||
| Synonyms | AOX1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | AOX1 | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Molybdopterin | Ligand Info | |||
| Canonical SMILES | C(C1C(=C(C2C(O1)NC3=C(N2)C(=O)NC(=N3)N)S)S)OP(=O)(O)O | ||||
| InChI | 1S/C10H14N5O6PS2/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16)/t2-,3+,9-/m1/s1 | ||||
| InChIKey | HPEUEJRPDGMIMY-IFQPEPLCSA-N | ||||
| PubChem Compound ID | 135398581 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4UHW Human aldehyde oxidase | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [1] |
| PDB Sequence |
ASELLFYVNG
13 RKVIEKNVDP23 ETMLLPYLRK33 KLRLTGTKYG43 CGGGGCGACT53 VMISRYNPIT 63 KRIRHHPANA73 CLIPICSLYG83 AAVTTVEGIG93 STHTRIHPVQ103 ERIAKCHGTQ 113 CGFCTPGMVM123 SIYTLLRNHP133 EPTLDQLTDA143 LGGNLCRCTG153 YRPIIDACKT 163 FCKTPKLFAE204 EEFLPLDPTQ214 ELIFPPELMI224 MAEKQSQRTR234 VFGSERMMWF 244 SPVTLKELLE254 FKFKYPQAPV264 IMGNTSVGPE274 VKFKGVFHPV284 IISPDRIEEL 294 SVVNHAYNGL304 TLGAGLSLAQ314 VKDILADVVQ324 KLPEEKTQMY334 HALLKHLGTL 344 AGSQIRNMAS354 LGGHIISRHP364 DSDLNPILAV374 GNCTLNLLSK384 EGKRQIPLNE 394 QFLSKCPNAD404 LKPQEILVSV414 NIPYSRKWEF424 VSAFRQAQRQ434 ENALAIVNSG 444 MRVFFGEGDG454 IIRELCISYG464 GVGPATICAK474 NSCQKLIGRH484 WNEQMLDIAC 494 RLILNEVSLL504 GSAPGGKVEF514 KRTLIISFLF524 KFYLEVSQIL534 KKMDPVHYPS 544 LADKYESALE554 DLHSHHCSTL565 KYQNPKQHPE577 DPIGHPIMHL587 SGVKHATGEA 597 IYCDDMPLVD607 QELFLTFVTS617 SRAHAKIVSI627 DLSEALSMPG637 VVDIMTAEHL 647 SDVNSFCKFL663 ATDKVFCVGQ673 LVCAVLADSE683 VQAKRAAKRV693 KIVYQDLEPL 703 ILTIEESIQS716 FKPERKLEYG726 NVDEAFKVVD736 QILEGEIHMG746 GQEHFYMETQ 756 SMLVVPKGED766 QEMDVYVSTQ776 FPKYIQDIVA786 STLKLPANKV796 MCHVRRVGGA 806 FGGKVLKTGI816 IAAVTAFAAN826 KHGRAVRCVL836 ERGEDMLITG846 GRHPYLGKYK 856 AGFMNDGRIL866 ALDMEHYSNA876 GASLSLFVIE888 MGLLKMDNAY898 KFPNLRCRGW 908 ACRTNLPSNT918 AFRGFGFPQA928 ALITESCITE938 VAAKCGLSPE948 KVRIINMYKE 958 IDQTPYKQEI968 NAKNLIQCWR978 ECMAMSSYSL988 RKVAVEKFNA998 ENYWKKKGLA 1008 MVPLKFPVGL1018 GSRAAGQAAA1028 LVHIYLDGSV1038 LVTHGGIEMG1048 QGVHTKMIQV 1058 VSRELRMPMS1068 NVHLRGTSTE1078 TVPNANISGG1088 SVVADLNGLA1098 VKDACQTLLK 1108 RLEPIISKNP1118 KGTWKDWAQT1128 AFDESINLSA1138 VGYFRGYESD1148 MNWEKGEGQP 1158 FEYFVYGAAC1168 SEVEIDCLTG1178 DHKNIRTDIV1188 MDVGCSINPA1198 IDIGQIEGAF 1208 IQGMGLYTIE1218 ELNYSPQGIL1228 HTRGPDQYKI1238 PAICDMPTEL1248 HIALLPPSQN 1258 SNTLYSSKGL1268 GESGVFLGCS1278 VFFAIHDAVS1288 AARQERGLHG1298 PLTLNSPLTP 1308 EKIRMACEDK1318 FTKMIPRDEP1328 GSYVPWNV
|
|||||
|
|
GLN113
3.263
CYS114
4.131
CYS151
3.244
GLY805
3.692
ALA806
2.820
PHE807
3.073
GLY808
4.055
PHE920
4.743
ARG921
3.469
MET1047
2.875
GLY1048
3.373
GLN1049
3.369
|
|||||
| PDB ID: 7OPN Human Aldehyde Oxidase SNP R1231H in complex with Raloxifene | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | Yes | [2] |
| PDB Sequence |
ASELLFYVNG
13 RKVIEKNVDP23 ETMLLPYLRK33 KLRLTGTKYG43 CGGGGCGACT53 VMISRYNPIT 63 KRIRHHPANA73 CLIPICSLYG83 AAVTTVEGIG93 STHTRIHPVQ103 ERIAKCHGTQ 113 CGFCTPGMVM123 SIYTLLRNHP133 EPTLDQLTDA143 LGGNLCRCTG153 YRPIIDACKT 163 FCKPKLFAEE205 EFLPLDPTQE215 LIFPPELMIM225 AEKQSQRTRV235 FGSERMMWFS 245 PVTLKELLEF255 KFKYPQAPVI265 MGNTSVGPEV275 KFKGVFHPVI285 ISPDRIEELS 295 VVNHAYNGLT305 LGAGLSLAQV315 KDILADVVQK325 LPEEKTQMYH335 ALLKHLGTLA 345 GSQIRNMASL355 GGHIISRHPD365 SDLNPILAVG375 NCTLNLLSKE385 GKRQIPLNEQ 395 FLSKCPNADL405 KPQEILVSVN415 IPYSRKWEFV425 SAFRQAQRQE435 NALAIVNSGM 445 RVFFGEGDGI455 IRELCISYGG465 VGPATICAKN475 SCQKLIGRHW485 NEQMLDIACR 495 LILNEVSLLG505 SAPGGKVEFK515 RTLIISFLFK525 FYLEVSQILK535 KMDPVHYPSL 545 ADKYESALED555 LHSKHHCSTL565 KYQNQHPEDP579 IGHPIMHLSG589 VKHATGEAIY 599 CDDMPLVDQE609 LFLTFVTSSR619 AHAKIVSIDL629 SEALSMPGVV639 DIMTAEHLSD 649 VNSFCFFTEA659 EKFLATDKVF669 CVGQLVCAVL679 ADSEVQAKRA689 AKRVKIVYQD 699 LEPLILTIEE709 SIQHNSSFKP719 ERKLEYGNVD729 EAFKVVDQIL739 EGEIHMGGQE 749 HFYMETQSML759 VVPKGEDQEM769 DVYVSTQFPK779 YIQDIVASTL789 KLPANKVMCH 799 VRRVGGAFGG809 KVLKTGIIAA819 VTAFAANKHG829 RAVRCVLERG839 EDMLITGGRH 849 PYLGKYKAGF859 MNDGRILALD869 MEHYSNAGAS879 LDESLFVIEM889 GLLKMDNAYK 899 FPNLRCRGWA909 CRTNLPSNTA919 FRGFGFPQAA929 LITESCITEV939 AAKCGLSPEK 949 VRIINMYKEI959 DQTPYKQEIN969 AKNLIQCWRE979 CMAMSSYSLR989 KVAVEKFNAE 999 NYWKKKGLAM1009 VPLKFPVGLG1019 SRAAGQAAAL1029 VHIYLDGSVL1039 VTHGGIEMGQ 1049 GVHTKMIQVV1059 SRELRMPMSN1069 VHLRGTSTET1079 VPNANISGGS1089 VVADLNGLAV 1099 KDACQTLLKR1109 LEPIISKNPK1119 GTWKDWAQTA1129 FDESINLSAV1139 GYFRGYESDM 1149 NWEKGEGQPF1159 EYFVYGAACS1169 EVEIDCLTGD1179 HKNIRTDIVM1189 DVGCSINPAI 1199 DIGQIEGAFI1209 QGMGLYTIEE1219 LNYSPQGILH1229 THGPDQYKIP1239 AICDMPTELH 1249 IALLPPSQNS1259 NTLYSSKGLG1269 ESGVFLGCSV1279 FFAIHDAVSA1289 ARQERGLHLT 1301 LNSPLTPEKI1311 RMACEDKFTK1321 MIPRDEPGSY1331 VPWNV
|
|||||
|
|
GLN113
3.065
CYS114
4.346
CYS151
3.338
GLN776
4.664
GLY805
3.707
ALA806
2.797
PHE807
2.951
GLY808
3.827
PHE920
4.862
ARG921
3.526
MET1047
3.144
GLY1048
3.509
|
|||||
| PDB ID: 4UHX Human aldehyde oxidase in complex with phthalazine and thioridazine | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [1] |
| PDB Sequence |
ASELLFYVNG
13 RKVIEKNVDP23 ETMLLPYLRK33 KLRLTGTKYG43 CGGGGCGACT53 VMISRYNPIT 63 KRIRHHPANA73 CLIPICSLYG83 AAVTTVEGIG93 STHTRIHPVQ103 ERIAKCHGTQ 113 CGFCTPGMVM123 SIYTLLRNHP133 EPTLDQLTDA143 LGGNLCRCTG153 YRPIIDACKT 163 FCKTPKLFAE204 EEFLPLDPTQ214 ELIFPPELMI224 MAEKQSQRTR234 VFGSERMMWF 244 SPVTLKELLE254 FKFKYPQAPV264 IMGNTSVGPE274 VKFKGVFHPV284 IISPDRIEEL 294 SVVNHAYNGL304 TLGAGLSLAQ314 VKDILADVVQ324 KLPEEKTQMY334 HALLKHLGTL 344 AGSQIRNMAS354 LGGHIISRHP364 DSDLNPILAV374 GNCTLNLLSK384 EGKRQIPLNE 394 QFLSKCPNAD404 LKPQEILVSV414 NIPYSRKWEF424 VSAFRQAQRQ434 ENALAIVNSG 444 MRVFFGEGDG454 IIRELCISYG464 GVGPATICAK474 NSCQKLIGRH484 WNEQMLDIAC 494 RLILNEVSLL504 GSAPGGKVEF514 KRTLIISFLF524 KFYLEVSQIL534 KKMDPVHYPS 544 LADKYESALE554 DLHSHHCSTL565 KYQNIGPKQH575 PEDPIGHPIM585 HLSGVKHATG 595 EAIYCDDMPL605 VDQELFLTFV615 TSSRAHAKIV625 SIDLSEALSM635 PGVVDIMTAE 645 HLSDVNSFCK661 FLATDKVFCV671 GQLVCAVLAD681 SEVQAKRAAK691 RVKIVYQDLE 701 PLILTIEESI711 QSFKPERKLE724 YGNVDEAFKV734 VDQILEGEIH744 MGGQEHFYME 754 TQSMLVVPKG764 EDQEMDVYVS774 TQFPKYIQDI784 VASTLKLPAN794 KVMCHVRRVG 804 GAFGGKVLKT814 GIIAAVTAFA824 ANKHGRAVRC834 VLERGEDMLI844 TGGRHPYLGK 854 YKAGFMNDGR864 ILALDMEHYS874 NAGASLSLFV886 IEMGLLKMDN896 AYKFPNLRCR 906 GWACRTNLPS916 NTAFRGFGFP926 QAALITESCI936 TEVAAKCGLS946 PEKVRIINMY 956 KEIDQTPYKQ966 EINAKNLIQC976 WRECMAMSSY986 SLRKVAVEKF996 NAENYWKKKG 1006 LAMVPLKFPV1016 GLGSRAAGQA1026 AALVHIYLDG1036 SVLVTHGGIE1046 MGQGVHTKMI 1056 QVVSRELRMP1066 MSNVHLRGTS1076 TETVPNANIS1086 GGSVVADLNG1096 LAVKDACQTL 1106 LKRLEPIISK1116 NPKGTWKDWA1126 QTAFDESINL1136 SAVGYFRGYE1146 SDMNWEKGEG 1156 QPFEYFVYGA1166 ACSEVEIDCL1176 TGDHKNIRTD1186 IVMDVGCSIN1196 PAIDIGQIEG 1206 AFIQGMGLYT1216 IEELNYSPQG1226 ILHTRGPDQY1236 KIPAICDMPT1246 ELHIALLPPS 1256 QNSNTLYSSK1266 GLGESGVFLG1276 CSVFFAIHDA1286 VSAARQERGL1296 HGPLTLNSPL 1306 TPEKIRMACE1316 DKFTKMIPRD1326 EPGSYVPWNV1336
|
|||||
|
|
GLN113
3.160
CYS114
4.151
CYS151
3.184
GLY805
3.709
ALA806
2.855
PHE807
3.154
GLY808
4.266
PHE920
4.683
ARG921
3.274
MET1047
2.995
GLY1048
3.405
GLN1049
3.446
|
|||||
| PDB ID: 7ORC Human Aldehyde Oxidase in complex with Raloxifene | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [2] |
| PDB Sequence |
ASELLFYVNG
13 RKVIEKNVDP23 ETMLLPYLRK33 KLRLTGTKYG43 CGGGGCGACT53 VMISRYNPIT 63 KRIRHHPANA73 CLIPICSLYG83 AAVTTVEGIG93 STHTRIHPVQ103 ERIAKCHGTQ 113 CGFCTPGMVM123 SIYTLLRNHP133 EPTLDQLTDA143 LGGNLCRCTG153 YRPIIDACKT 163 FCKLFAEEEF207 LPLDPTQELI217 FPPELMIMAE227 KQSQRTRVFG237 SERMMWFSPV 247 TLKELLEFKF257 KYPQAPVIMG267 NTSVGPEVKF277 KGVFHPVIIS287 PDRIEELSVV 297 NHAYNGLTLG307 AGLSLAQVKD317 ILADVVQKLP327 EEKTQMYHAL337 LKHLGTLAGS 347 QIRNMASLGG357 HIISRHPDSD367 LNPILAVGNC377 TLNLLSKEGK387 RQIPLNEQFL 397 SKCPNADLKP407 QEILVSVNIP417 YSRKWEFVSA427 FRQAQRQENA437 LAIVNSGMRV 447 FFGEGDGIIR457 ELCISYGGVG467 PATICAKNSC477 QKLIGRHWNE487 QMLDIACRLI 497 LNEVSLLGSA507 PGGKVEFKRT517 LIISFLFKFY527 LEVSQILKKM537 DPVHYPSLAD 547 KYESALEDLH557 SKHHCSTLKY567 QNPKQHPEDP579 IGHPIMHLSG589 VKHATGEAIY 599 CDDMPLVDQE609 LFLTFVTSSR619 AHAKIVSIDL629 SEALSMPGVV639 DIMTAEHLSD 649 VNSFCFFTEA659 EKFLATDKVF669 CVGQLVCAVL679 ADSEVQAKRA689 AKRVKIVYQD 699 LEPLILTIEE709 SIQHNSSFKP719 ERKLEYGNVD729 EAFKVVDQIL739 EGEIHMGGQE 749 HFYMETQSML759 VVPKGEDQEM769 DVYVSTQFPK779 YIQDIVASTL789 KLPANKVMCH 799 VRRVGGAFGG809 KVLKTGIIAA819 VTAFAANKHG829 RAVRCVLERG839 EDMLITGGRH 849 PYLGKYKAGF859 MNDGRILALD869 MEHYSNAGAS879 LDESLFVIEM889 GLLKMDNAYK 899 FPNLRCRGWA909 CRTNLPSNTA919 FRGFGFPQAA929 LITESCITEV939 AAKCGLSPEK 949 VRIINMYKEI959 DQTPYKQEIN969 AKNLIQCWRE979 CMAMSSYSLR989 KVAVEKFNAE 999 NYWKKKGLAM1009 VPLKFPVGLG1019 SRAAGQAAAL1029 VHIYLDGSVL1039 VTHGGIEMGQ 1049 GVHTKMIQVV1059 SRELRMPMSN1069 VHLRGTSTET1079 VPNANISGGS1089 VVADLNGLAV 1099 KDACQTLLKR1109 LEPIISKNPK1119 GTWKDWAQTA1129 FDESINLSAV1139 GYFRGYESDM 1149 NWEKGEGQPF1159 EYFVYGAACS1169 EVEIDCLTGD1179 HKNIRTDIVM1189 DVGCSINPAI 1199 DIGQIEGAFI1209 QGMGLYTIEE1219 LNYSPQGILH1229 TRGPDQYKIP1239 AICDMPTELH 1249 IALLPPSQNS1259 NTLYSSKGLG1269 ESGVFLGCSV1279 FFAIHDAVSA1289 ARQERGLHLT 1301 LNSPLTPEKI1311 RMACEDKFTK1321 MIPRDEPGSY1331 VPWNV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MTE or .MTE2 or .MTE3 or :3MTE;style chemicals stick;color identity;select .A:113 or .A:114 or .A:151 or .A:776 or .A:805 or .A:806 or .A:807 or .A:808 or .A:920 or .A:921 or .A:1047 or .A:1048 or .A:1049 or .A:1051 or .A:1086 or .A:1087 or .A:1088 or .A:1089 or .A:1090 or .A:1091 or .A:1092 or .A:1203 or .A:1268 or .A:1269 or .A:1270; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN113
2.879
CYS114
4.259
CYS151
3.566
GLN776
4.660
GLY805
3.812
ALA806
2.936
PHE807
2.990
GLY808
3.897
PHE920
4.991
ARG921
3.447
MET1047
2.916
GLY1048
3.196
GLN1049
3.281
|
|||||
| PDB ID: 5EPG Human aldehyde oxidase SNP S1271L | ||||||
| Method | X-ray diffraction | Resolution | 3.39 Å | Mutation | Yes | [3] |
| PDB Sequence |
ASELLFYVNG
13 RKVIEKNVDP23 ETMLLPYLRK33 KLRLTGTKYG43 CGGGGCGACT53 VMISRYNPIT 63 KRIRHHPANA73 CLIPICSLYG83 AAVTTVEGIG93 STHTRIHPVQ103 ERIAKCHGTQ 113 CGFCTPGMVM123 SIYTLLRNHP133 EPTLDQLTDA143 LGGNLCRCTG153 YRPIIDACKT 163 FCKTPKLFAE204 EEFLPLDPTQ214 ELIFPPELMI224 MAEKQSQRTR234 VFGSERMMWF 244 SPVTLKELLE254 FKFKYPQAPV264 IMGNTSVGPE274 VKFKGVFHPV284 IISPDRIEEL 294 SVVNHAYNGL304 TLGAGLSLAQ314 VKDILADVVQ324 KLPEEKTQMY334 HALLKHLGTL 344 AGSQIRNMAS354 LGGHIISRHP364 DSDLNPILAV374 GNCTLNLLSK384 EGKRQIPLNE 394 QFLSKCPNAD404 LKPQEILVSV414 NIPYSRKWEF424 VSAFRQAQRQ434 ENALAIVNSG 444 MRVFFGEGDG454 IIRELCISYG464 GVGPATICAK474 NSCQKLIGRH484 WNEQMLDIAC 494 RLILNEVSLL504 GSAPGGKVEF514 KRTLIISFLF524 KFYLEVSQIL534 KKMDPVHYPS 544 LADKYESALE554 DLHSHHCSTL565 KYQNPKQHPE577 DPIGHPIMHL587 SGVKHATGEA 597 IYCDDMPLVD607 QELFLTFVTS617 SRAHAKIVSI627 DLSEALSMPG637 VVDIMTAEHL 647 SDVNSFCKFL663 ATDKVFCVGQ673 LVCAVLADSE683 VQAKRAAKRV693 KIVYQDLEPL 703 ILTIEESIQS716 FKPERKLEYG726 NVDEAFKVVD736 QILEGEIHMG746 GQEHFYMETQ 756 SMLVVPKGED766 QEMDVYVSTQ776 FPKYIQDIVA786 STLKLPANKV796 MCHVRRVGGA 806 FGGKVLKTGI816 IAAVTAFAAN826 KHGRAVRCVL836 ERGEDMLITG846 GRHPYLGKYK 856 AGFMNDGRIL866 ALDMEHYSNA876 GASLSLFVIE888 MGLLKMDNAY898 KFPNLRCRGW 908 ACRTNLPSNT918 AFRGFGFPQA928 ALITESCITE938 VAAKCGLSPE948 KVRIINMYKE 958 IDQTPYKQEI968 NAKNLIQCWR978 ECMAMSSYSL988 RKVAVEKFNA998 ENYWKKKGLA 1008 MVPLKFPVGL1018 GSRAAGQAAA1028 LVHIYLDGSV1038 LVTHGGIEMG1048 QGVHTKMIQV 1058 VSRELRMPMS1068 NVHLRGTSTE1078 TVPNANISGG1088 SVVADLNGLA1098 VKDACQTLLK 1108 RLEPIISKNP1118 KGTWKDWAQT1128 AFDESINLSA1138 VGYFRGYESD1148 MNWEKGEGQP 1158 FEYFVYGAAC1168 SEVEIDCLTG1178 DHKNIRTDIV1188 MDVGCSINPA1198 IDIGQIEGAF 1208 IQGMGLYTIE1218 ELNYSPQGIL1228 HTRGPDQYKI1238 PAICDMPTEL1248 HIALLPPSQN 1258 SNTLYSSKGL1268 GELGVFLGCS1278 VFFAIHDAVS1288 AARQERGLHG1298 PLTLNSPLTP 1308 EKIRMACEDK1318 FTKMIPRDEP1328 GSYVPWNV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MTE or .MTE2 or .MTE3 or :3MTE;style chemicals stick;color identity;select .A:113 or .A:114 or .A:151 or .A:776 or .A:805 or .A:806 or .A:807 or .A:808 or .A:920 or .A:921 or .A:1047 or .A:1048 or .A:1049 or .A:1051 or .A:1086 or .A:1087 or .A:1088 or .A:1089 or .A:1090 or .A:1091 or .A:1092 or .A:1203 or .A:1268 or .A:1269 or .A:1270; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLN113
3.406
CYS114
4.077
CYS151
2.947
GLN776
4.774
GLY805
3.559
ALA806
2.665
PHE807
2.895
GLY808
3.599
PHE920
4.554
ARG921
3.534
MET1047
2.751
GLY1048
3.377
GLN1049
3.409
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. Nat Chem Biol. 2015 Oct;11(10):779-83. | ||||
| REF 2 | Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case. J Med Chem. 2021 Sep 9;64(17):13025-13037. | ||||
| REF 3 | Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms. Drug Metab Dispos. 2016 Aug;44(8):1277-85. | ||||
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