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| Target General Information |
Top |
| Target ID |
T34234 |
Target Info
|
| Target Name |
Vitamin D3 receptor (VDR) |
| Synonyms |
Vitamin D(3) receptor; Nuclear vitamin D receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1; 1,25-dihydroxyvitamin D3 receptor |
| Target Type |
Successful Target |
| Gene Name |
VDR |
| Biochemical Class |
Nuclear hormone receptor |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-27b-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
uucacaguggcuaaguucugc
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
VDR protein was downregulated by miR-27b. |
[1] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
qRT-PCR; Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
Adenosine A2b receptor (ADORA2B)
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Target Info
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|
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Albendazole monooxygenase (CYP3A4)
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Target Info
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| References |
Top |
| REF 1 |
MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos. 2009 Oct;37(10):2112-7.
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| REF 2 |
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines. Anticancer Res. 2012 Jan;32(1):383-9.
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