Target Regulator(s) Information (MicroRNA)

Content Navigation (  All   None )                                      
Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T57278 Target Info
Target Name Ephrin type-A receptor 2 (EPHA2)
Synonyms Tyrosine-protein kinase receptor ECK; Epithelial cell kinase; EphA2receptor; ECK
Target Type Clinical trial Target
Gene Name EPHA2
Biochemical Class Kinase
UniProt ID
P29317
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-26b-5p miRNA Info
miRNA Mature AC
MIMAT0000083
Sequence uucaaguaauucaggauaggu
miRNA Species Homo sapiens
Regulation Mechanism miR-26b inhibits hepatocellular carcinoma cell proliferation, migration, and invasion by targeting EphA2. [4]
Evidence Score (E-score) 4 +
Representative Target(s) Regulated by This miRNA ATP-binding cassette transporter A1 (ABCA1) Target Info
ABCA1_HUMAN
Collagen I (COL1A2) Target Info
CO1A2_HUMAN
miRNA Mature ID hsa-miR-520d-3p miRNA Info
miRNA Mature AC
MIMAT0002856
Sequence aaagugcuucucuuuggugggu
miRNA Species Homo sapiens
Regulation Mechanism EphA2 Is a Direct Functional Target of miR-520d-3p. [6]
Evidence Score (E-score) 2 +
Representative Target(s) Regulated by This miRNA Ephrin type-A receptor 2 (EPHA2) Target Info
EPHA2_HUMAN
References  Top
REF 1 MicroRNA-26b Enhances the Radiosensitivity of Hepatocellular Carcinoma Cells by Targeting EphA2. Tohoku J Exp Med. 2016 Feb;238(2):143-51.
REF 2 miR-26b enhances radiosensitivity of hepatocellular carcinoma cells by targeting EphA2. Iran J Basic Med Sci. 2016 Aug;19(8):851-857.
REF 3 Role of microRNA-26b in glioma development and its mediated regulation on EphA2. PLoS One. 2011 Jan 14;6(1):e16264.
REF 4 MiR-26b inhibits hepatocellular carcinoma cell proliferation, migration, and invasion by targeting EphA2. Int J Clin Exp Pathol. 2015 May 1;8(5):4782-90.
REF 5 MicroRNA 520d-3p inhibits gastric cancer cell proliferation, migration, and invasion by downregulating EphA2 expression. Mol Cell Biochem. 2014 Nov;396(1-2):295-305.
REF 6 Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discov. 2013 Nov;3(11):1302-15.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.