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| Target General Information |
Top |
| Target ID |
T00140 |
Target Info
|
| Target Name |
Arachidonate 5-lipoxygenase (5-LOX) |
| Synonyms |
LOG5; 5-lipoxygenase; 5-LO |
| Target Type |
Successful Target |
| Gene Name |
ALOX5 |
| Biochemical Class |
Oxygenase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Actins |
[+] 1 Actins |
+ |
| Interacting Protein Name |
Coactosin-like protein (COTL1) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
CLP |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Yeast two hybrid |
[1] |
| Lyases |
[+] 1 Lyases |
+ |
| Interacting Target Name |
Arachidonate 5-lipoxygenase activating protein (FLAP) |
Discontinued Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
MK-886-binding protein; FLAP; ALOX5AP |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Co-localization |
[2] |
| 2 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
5-Lipoxygenase interacts with coactosin-like protein. J Biol Chem. 2001 May 11;276(19):16520-7.
|
| REF 2 |
Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes. FASEB J. 2016 Jan;30(1):276-85.
|
| REF 3 |
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. Biochem Biophys Res Commun. 2009 Apr 17;381(4):518-22.
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