| References |
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| REF 1 |
LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res. 2008 Jun 10;314(10):2055-65.
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| REF 2 |
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015 Sep 10;11(9):e1005503.
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| REF 3 |
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J Biol Chem. 2011 May 6;286(18):16140-9.
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| REF 4 |
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One. 2010 Oct 29;5(10):e13762.
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| REF 5 |
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2897-902.
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| REF 6 |
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLoS One. 2009 Jun 17;4(6):e5949.
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| REF 7 |
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. Biochem J. 2017 Apr 24;474(9):1547-1558.
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| REF 8 |
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Proteomics. 2018 May;18(10):e1700444.
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| REF 9 |
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31.
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| REF 10 |
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010 Sep 15;430(3):393-404.
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| REF 11 |
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci. 2008 Mar 26;28(13):3384-91.
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| REF 12 |
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. Biochem J. 2012 Aug 15;446(1):99-111.
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| REF 13 |
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet. 2006 Jan 15;15(2):223-32.
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| REF 14 |
Identification of potential protein interactors of Lrrk2. Parkinsonism Relat Disord. 2007 Oct;13(7):382-5.
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| REF 15 |
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature. 2010 Jul 29;466(7306):637-41.
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| REF 16 |
Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J Biol Chem. 2009 Dec 25;284(52):36346-56.
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| REF 17 |
Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. PLoS One. 2010 Oct 7;5(10):e13191.
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| REF 18 |
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010 Mar;112(6):1593-604.
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| REF 19 |
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem. 2009 May;109(4):959-68.
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| REF 20 |
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis. 2010;7(1-3):68-75.
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| REF 21 |
ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J Neurosci. 2012 Mar 14;32(11):3877-86.
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| REF 22 |
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet. 2012;8(2):e1002526.
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| REF 23 |
Screening of LRRK2 interactants by yeast 2-hybrid analysis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):883-91.
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| REF 24 |
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS One. 2012;7(1):e30834.
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| REF 25 |
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci. 2010 Dec 15;30(50):16959-69.
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| REF 26 |
A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol Cell Proteomics. 2011 Jan;10(1):M110.001172.
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