Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14181 Target Info
Target Name Telomeric repeat-binding factor 2 (TERF2)
Synonyms Telomeric DNA-binding protein; TTAGGG repeat-binding factor 2; TRF2; TRBF2
Target Type Literature-reported Target
Gene Name TERF2
UniProt ID
TERF2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 3 Acid anhydride hydrolases +
Interacting Protein Name DNA repair protein RAD50 (RAD50) Interacting Protein Interacting Protein Info
UniProt ID
RAD50_HUMAN 
Synonyms NBSLD; RAD502; hRad50
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
4 Affinity Capture-Western [3]
Interacting Protein Name Werner syndrome ATP-dependent helicase (WRN) Interacting Protein Interacting Protein Info
UniProt ID
WRN_HUMAN 
Synonyms RECQ3; RECQL2; RECQL3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Affinity Capture-Western [3]
3 Reconstituted Complex [4]
Interacting Target Name X-ray repair cross-complementing 5 (Ku80) Literature-reported Target Interacting Protein Info
UniProt ID
XRCC5_HUMAN 
Synonyms X-ray repair cross-complementing protein 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); TLAA; Thyroid-lupus autoantigen; Nuclear factor IV; Lupus Ku autoantigen protein p86; Ku86; G22P2; DNA repair protein XRCC5; CTCBF; CTC85; CTC box-binding factor 85 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase 2 subunit 2; 86 kDa subunit of Ku antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [2]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name DNA cross-link repair 1B protein (DCLRE1B) Interacting Protein Interacting Protein Info
UniProt ID
DCR1B_HUMAN 
Synonyms APOLLO; SNM1B; SNMIB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [7]
3 Reconstituted Complex [7]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) Interacting Protein Interacting Protein Info
UniProt ID
TE2IP_HUMAN 
Synonyms DRIP5; RAP1
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Co-fractionation [10]
8 Co-localization [9]
9 Reconstituted Complex [11]
10 Yeast two hybrid [6]
11 Yeast two hybrid [12]
12 Yeast two hybrid [13]
Interacting Protein Name TERF1-interacting nuclear factor 2 (TINF2) Interacting Protein Interacting Protein Info
UniProt ID
TINF2_HUMAN 
Synonyms DKCA3; TIN2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [14]
3 Affinity Capture-Western [15]
4 Far Western [16]
5 Yeast two hybrid [12]
Interacting Protein Name Structure-specific endonuclease subunit SLX4 (SLX4) Interacting Protein Interacting Protein Info
UniProt ID
SLX4_HUMAN 
Synonyms BTBD12; FANCP; MUS312
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Affinity Capture-Western [18]
3 Co-localization [18]
4 Yeast two hybrid [17]
Interacting Protein Name Protection of telomeres protein 1 (POT1) Interacting Protein Interacting Protein Info
UniProt ID
POTE1_HUMAN 
Synonyms CMM10; HPOT1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [14]
References  Top
REF 1 Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet. 2000 Jul;25(3):347-52.
REF 2 The human Rap1 protein complex and modulation of telomere length. J Biol Chem. 2004 Jul 2;279(27):28585-91.
REF 3 WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar;28(6):1892-904.
REF 4 Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem. 2002 Oct 25;277(43):41110-9.
REF 5 The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One. 2010 Aug 25;5(8):e12407.
REF 6 A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol. 2011 Feb;18(2):213-21.
REF 7 The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr Biol. 2006 Jul 11;16(13):1303-10.
REF 8 PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2. FEBS Lett. 2015 Oct 24;589(21):3277-86.
REF 9 Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites. Epigenetics Chromatin. 2017 Nov 10;10(1):54.
REF 10 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 11 Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J Biol Chem. 2012 Dec 7;287(50):41583-94.
REF 12 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics. 2011 Feb;10(2):M110.001628.
REF 13 NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation. FEBS Lett. 2016 Jun;590(12):1776-90.
REF 14 Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem. 2004 Dec 3;279(49):51338-42.
REF 15 p300-mediated acetylation of TRF2 is required for maintaining functional telomeres. Nucleic Acids Res. 2013 Feb 1;41(4):2267-83.
REF 16 TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem. 2004 Nov 5;279(45):47264-71.
REF 17 Localization-dependent and -independent roles of SLX4 in regulating telomeres. Cell Rep. 2013 Sep 12;4(5):853-60.
REF 18 SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 2013 Sep 12;4(5):861-9.

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