Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14894 Target Info
Target Name Caspase-10 (CASP10)
Synonyms MCH4; ICE-like apoptotic protease 4; FLICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP-10; Apoptotic protease Mch-4
Target Type Patented-recorded Target
Gene Name CASP10
Biochemical Class Peptidase
UniProt ID
CASPA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-purification [4]
3 Fluorescence Resonance Energy Transfer [5]
4 Reconstituted Complex [6]
5 Yeast two hybrid [1]
Peptidases [+] 2 Peptidases +
Interacting Target Name CASP8-FADD-like regulator (CFLAR) Literature-reported Target Interacting Protein Info
UniProt ID
CFLAR_HUMAN 
Synonyms Usurpin; MRIT; MACH-related inducer of toxicity; MACHrelated inducer of toxicity; Inhibitor of FLICE; I-FLICE; IFLICE; FLAME-1; FLAME1; FADD-like antiapoptotic molecule 1; FADDlike antiapoptotic molecule 1; CLARP; c-FLIP; cFLIP; Cellular FLICE-like inhibitory protein; Cellular FLICElike inhibitory protein; Casper; Caspase-like apoptosis regulatory protein; Caspaselike apoptosis regulatory protein; Caspase-eight-related protein; Caspaseeightrelated protein; Caspase homolog; CASP8AP1; CASP8 and FADDlike apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator; CASP8 and FADDlike apoptosis regulator; CASH
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
3 Reconstituted Complex [3]
4 Yeast two hybrid [9]
Interacting Target Name Caspase-8 (CASP8) Patented-recorded Target Interacting Protein Info
UniProt ID
CASP8_HUMAN 
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
3 Co-purification [4]
Other proteins [+] 1 Other proteins +
Interacting Target Name Apoptosis mediating surface antigen FAS (FAS) Clinical trial Target Interacting Protein Info
UniProt ID
TNR6_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 6; TNFRSF6; FASLG receptor; FAS1; CD95; APT1; Apoptosis-mediating surface antigen FAS; Apo-1 antigen
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-purification [4]
References  Top
REF 1 Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6170-5.
REF 2 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 3 FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem. 1997 Jul 25;272(30):18542-5.
REF 4 Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005 Mar 25;280(12):11641-7.
REF 5 Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13884-8.
REF 6 Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase. Cell Death Differ. 2011 Mar;18(3):405-14.
REF 7 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011 Aug 5;43(3):449-63.
REF 8 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 9 CASH, a novel caspase homologue with death effector domains. J Biol Chem. 1997 Aug 8;272(32):19641-4.
REF 10 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003 Jul 25;114(2):181-90.
REF 11 Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14486-91.
REF 12 Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J Biol Chem. 1997 Mar 7;272(10):6578-83.

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