Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | CASP8-FADD-like regulator (CFLAR) | Literature-reported | Target Info | ||
| UniProt ID | CFLAR_HUMAN | ||||
| Gene Name | CFLAR | ||||
| Gene ID | 8837 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | Caspase-3 (CASP3) | Target Info | PPI Info | [1] | |
| Proto-oncogene c-RAF (c-RAF) | Target Info | PPI Info | [2] | ||
| Interacting Patented-recorded Target(s) | Caspase-8 (CASP8) | Target Info | PPI Info | [3] | |
| Caspase-10 (CASP10) | Target Info | PPI Info | [4] | ||
| Interacting Literature-reported Target(s) | CASP8-FADD-like regulator (CFLAR) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63. | ||||
| REF 2 | The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol. 2000 Jun 1;10(11):640-8. | ||||
| REF 3 | Identification and characterization of DEDD2, a death effector domain-containing protein. J Biol Chem. 2002 Mar 1;277(9):7501-8. | ||||
| REF 4 | CASH, a novel caspase homologue with death effector domains. J Biol Chem. 1997 Aug 8;272(32):19641-4. | ||||
| REF 5 | c-FLIP is a target of the E3 ligase deltex1 in gastric cancer. Cell Death Dis. 2018 Jan 26;9(2):135. | ||||
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