Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T57943 Target Info
Target Name Caspase-3 (CASP3)
Synonyms Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; Caspase 3; CPP32; CPP-32; CASP-3; Apopain
Target Type Clinical trial Target
Gene Name CASP3
Biochemical Class Peptidase
UniProt ID
CASP3_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 4 Acyltransferases +
Interacting Target Name X-linked inhibitor of apoptosis protein (XIAP) Clinical trial Target Interacting Protein Info
UniProt ID
XIAP_HUMAN 
Synonyms X-linked IAP; Xlinked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAP-like protein; IAPlike protein; IAP-3; IAP3; hILP; hIAP-3; hIAP3; E3 ubiquitin-protein ligase XIAP; E3 ubiquitinprotein ligase XIAP; BIRC4; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeatcontaining protein 4; API3
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Biochemical Activity [5]
6 Co-crystal Structure [6]
7 Reconstituted Complex [7]
8 Reconstituted Complex [8]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
3 Reconstituted Complex [10]
Interacting Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC3_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 1; TNFR2TRAFsignaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; hIAP-1; hIAP1; C-IAP2; CIAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [11]
Interacting Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target Interacting Protein Info
UniProt ID
BIRC7_HUMAN 
Synonyms UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [13]
Peptidases [+] 2 Peptidases +
Interacting Target Name Caspase-9 (CASP9) Clinical trial Target Interacting Protein Info
UniProt ID
CASP9_HUMAN 
Synonyms MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; APAF-3
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [14]
2 Biochemical Activity [15]
3 Biochemical Activity [5]
4 Co-localization [16]
Interacting Target Name CASP8-FADD-like regulator (CFLAR) Literature-reported Target Interacting Protein Info
UniProt ID
CFLAR_HUMAN 
Synonyms Usurpin; MRIT; MACH-related inducer of toxicity; MACHrelated inducer of toxicity; Inhibitor of FLICE; I-FLICE; IFLICE; FLAME-1; FLAME1; FADD-like antiapoptotic molecule 1; FADDlike antiapoptotic molecule 1; CLARP; c-FLIP; cFLIP; Cellular FLICE-like inhibitory protein; Cellular FLICElike inhibitory protein; Casper; Caspase-like apoptosis regulatory protein; Caspaselike apoptosis regulatory protein; Caspase-eight-related protein; Caspaseeightrelated protein; Caspase homolog; CASP8AP1; CASP8 and FADDlike apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator; CASP8 and FADDlike apoptosis regulator; CASH
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
3 Yeast two hybrid [18]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [19]
2 Biochemical Activity [20]
3 Biochemical Activity [21]
4 Co-localization [16]
Other proteins [+] 5 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 4 Experimental Evidences +
1 Biochemical Activity [22]
2 Biochemical Activity [23]
3 Biochemical Activity [24]
4 Co-localization [16]
Interacting Protein Name Hematopoietic lineage cell-specific protein (HCLS1) Interacting Protein Interacting Protein Info
UniProt ID
HCLS1_HUMAN 
Synonyms CTTNL; HS1; lckBP1; p75
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [25]
2 Biochemical Activity [26]
3 Co-localization [16]
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [27]
2 Reconstituted Complex [28]
Interacting Target Name DNA fragmentation factor alpha (DFFA) Literature-reported Target Interacting Protein Info
UniProt ID
DFFA_HUMAN 
Synonyms Inhibitor of caspase-3-activated Dnase; Inhibitor of CAD; ICAD; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF-45; DFF45; DFF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Co-localization [16]
Interacting Protein Name Src substrate cortactin (CTTN) Interacting Protein Interacting Protein Info
UniProt ID
SRC8_HUMAN 
Synonyms EMS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [26]
2 Co-localization [16]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 3 Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP-caspase interaction. FEBS J. 2006 Aug;273(16):3837-49.
REF 4 Expression of B-crystallin overrides the anti-apoptotic activity of XIAP. Neuro Oncol. 2012 Nov;14(11):1332-45.
REF 5 Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12815-9.
REF 6 Structural basis for the inhibition of caspase-3 by XIAP. Cell. 2001 Mar 9;104(5):791-800.
REF 7 A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem. 1998 Apr 3;273(14):7787-90.
REF 8 X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997 Jul 17;388(6639):300-4.
REF 9 IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells. PLoS Pathog. 2006 Oct;2(10):e114.
REF 10 The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 8;284(19):12772-82.
REF 11 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 1997 Dec 1;16(23):6914-25.
REF 12 Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3. Int J Oncol. 2013 Jun;42(6):2037-45.
REF 13 Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001 Feb 2;276(5):3238-46.
REF 14 Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J. 2007 Jul 1;405(1):11-9.
REF 15 The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J Biol Chem. 2005 Jan 7;280(1):174-82.
REF 16 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 17 Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63.
REF 18 MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11333-8.
REF 19 A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene. 1998 Nov 19;17(20):2629-36.
REF 20 Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J Biol Chem. 1997 Sep 5;272(36):22966-73.
REF 21 Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Mol Cell Biol. 2014 Aug;34(15):2800-10.
REF 22 Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. Eur J Biochem. 1998 Oct 1;257(1):242-8.
REF 23 Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell. 1998 Mar;1(4):553-63.
REF 24 Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene. 1999 Feb 4;18(5):1131-8.
REF 25 Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem J. 2002 May 15;364(Pt 1):41-7.
REF 26 Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. Biochem Biophys Res Commun. 2001 Nov 9;288(4):981-9.
REF 27 An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. 2001 Jan 30;40(4):1117-23.
REF 28 IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998 Dec 1;58(23):5315-20.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.