Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T15700 Target Info
Target Name Caspase-8 (CASP8)
Synonyms MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
Target Type Patented-recorded Target
Gene Name CASP8
Biochemical Class Peptidase
UniProt ID
CASP8_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [1]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [2]
2 Fluorescence Resonance Energy Transfer [3]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name FAS-associated death domain protein (FADD) Interacting Protein Interacting Protein Info
UniProt ID
FADD_HUMAN 
Synonyms MORT1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-purification [5]
3 Reconstituted Complex [6]
4 Yeast two hybrid [7]
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [9]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name B-cell receptor-associated protein 31 (BCAP31) Interacting Protein Interacting Protein Info
UniProt ID
BAP31_HUMAN 
Synonyms 6C6.AG; BAP31; CDM; DDCH; DXS1357E
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
Kinases [+] 1 Kinases +
Interacting Target Name Receptor-interacting protein 1 (RIPK1) Clinical trial Target Interacting Protein Info
UniProt ID
RIPK1_HUMAN 
Synonyms RIP-1; RIP1; RIP; Receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-fractionation [12]
Peptidases [+] 2 Peptidases +
Interacting Target Name Caspase-10 (CASP10) Patented-recorded Target Interacting Protein Info
UniProt ID
CASPA_HUMAN 
Synonyms MCH4; ICE-like apoptotic protease 4; FLICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP-10; Apoptotic protease Mch-4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [13]
Interacting Target Name CASP8-FADD-like regulator (CFLAR) Literature-reported Target Interacting Protein Info
UniProt ID
CFLAR_HUMAN 
Synonyms Usurpin; MRIT; MACH-related inducer of toxicity; MACHrelated inducer of toxicity; Inhibitor of FLICE; I-FLICE; IFLICE; FLAME-1; FLAME1; FADD-like antiapoptotic molecule 1; FADDlike antiapoptotic molecule 1; CLARP; c-FLIP; cFLIP; Cellular FLICE-like inhibitory protein; Cellular FLICElike inhibitory protein; Casper; Caspase-like apoptosis regulatory protein; Caspaselike apoptosis regulatory protein; Caspase-eight-related protein; Caspaseeightrelated protein; Caspase homolog; CASP8AP1; CASP8 and FADDlike apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator; CASP8 and FADDlike apoptosis regulator; CASH
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [15]
Other proteins [+] 4 Other proteins +
Interacting Target Name TRAIL receptor 1 (TRAIL-R1) Clinical trial Target Interacting Protein Info
UniProt ID
TR10A_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 10A; TRAILR1; TNF-related apoptosis-inducing ligand receptor 1; DR4; Death receptor 4; CD261; APO2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [17]
3 Biochemical Activity [15]
Interacting Target Name Apoptosis mediating surface antigen FAS (FAS) Clinical trial Target Interacting Protein Info
UniProt ID
TNR6_HUMAN 
Synonyms Tumor necrosis factor receptor superfamily member 6; TNFRSF6; FASLG receptor; FAS1; CD95; APT1; Apoptosis-mediating surface antigen FAS; Apo-1 antigen
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [18]
3 Co-purification [5]
Interacting Target Name TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Interacting Protein Info
UniProt ID
TR10B_HUMAN 
Synonyms ZTNFR9; UNQ160/PRO186; Tumor necrosis factor receptor superfamily member 10B; TRICK2; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; KILLER; DR5; Death receptor 5; CD262
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-purification [5]
Interacting Protein Name Death effector domain-containing protein (DEDD) Interacting Protein Interacting Protein Info
UniProt ID
DEDD_HUMAN 
Synonyms CASP8IP1; DEDD1; DEFT; FLDED1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Reconstituted Complex [21]
References  Top
REF 1 Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-B and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017 Sep;24(9):1621-1631.
REF 2 Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Curr Biol. 2006 Aug 22;16(16):1666-71.
REF 3 TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB. J Biol Chem. 2006 Apr 21;281(16):11235-49.
REF 4 ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Feb 12;457(7231):906-9.
REF 5 Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005 Mar 25;280(12):11641-7.
REF 6 DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2012 Mar 8;31(10):1311-22.
REF 7 Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996 Jun 14;85(6):803-15.
REF 8 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003 Jul 25;114(2):181-90.
REF 9 TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J Biol Chem. 2001 Mar 16;276(11):8087-93.
REF 10 Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J. 2011 Feb 2;30(3):556-68.
REF 11 p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol. 1997 Oct 20;139(2):327-38.
REF 12 A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
REF 13 Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem. 2002 Apr 19;277(16):13430-7.
REF 14 Identification and characterization of DEDD2, a death effector domain-containing protein. J Biol Chem. 2002 Mar 1;277(9):7501-8.
REF 15 PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 2009 Sep;16(9):1215-26.
REF 16 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 17 Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997 Oct 10;272(41):25417-20.
REF 18 Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63.
REF 19 DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells. Mol Oncol. 2017 Dec;11(12):1733-1751.
REF 20 DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003 Jan 16;22(2):291-7.
REF 21 DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86.

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