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Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-B and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017 Sep;24(9):1621-1631.
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Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Curr Biol. 2006 Aug 22;16(16):1666-71.
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TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB. J Biol Chem. 2006 Apr 21;281(16):11235-49.
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ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature. 2009 Feb 12;457(7231):906-9.
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Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005 Mar 25;280(12):11641-7.
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DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2012 Mar 8;31(10):1311-22.
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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996 Jun 14;85(6):803-15.
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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003 Jul 25;114(2):181-90.
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TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J Biol Chem. 2001 Mar 16;276(11):8087-93.
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Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J. 2011 Feb 2;30(3):556-68.
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p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol. 1997 Oct 20;139(2):327-38.
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A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov. 2012 Feb;2(2):140-55.
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Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem. 2002 Apr 19;277(16):13430-7.
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Identification and characterization of DEDD2, a death effector domain-containing protein. J Biol Chem. 2002 Mar 1;277(9):7501-8.
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PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 2009 Sep;16(9):1215-26.
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Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
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Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem. 1997 Oct 10;272(41):25417-20.
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Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997 Jun;6(6):751-63.
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DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells. Mol Oncol. 2017 Dec;11(12):1733-1751.
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DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003 Jan 16;22(2):291-7.
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REF 21 |
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. 1998 Oct 15;17(20):5974-86.
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