Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16180 Target Info
Target Name Transcription factor E2F2 (E2F2)
Synonyms E2F-2
Target Type Literature-reported Target
Gene Name E2F2
UniProt ID
E2F2_HUMAN 
Target Interacting Proteins  Top
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
Other proteins [+] 1 Other proteins +
Interacting Target Name Bromodomain-containing protein 2 (BRD2) Clinical trial Target Interacting Protein Info
UniProt ID
BRD2_HUMAN 
Synonyms RING3; Really interesting new gene 3 protein; O27.1.1; KIAA9001
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-purification [5]
References  Top
REF 1 Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007 Apr 18;26(8):2083-93.
REF 2 Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes Dev. 2002 Dec 15;16(24):3199-212.
REF 3 The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993 Dec;13(12):7813-25.
REF 4 Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Mol Endocrinol. 2002 Aug;16(8):1727-37.
REF 5 RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000 Aug;11(8):417-24.

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